| pubmed-article:16893618 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16893618 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:16893618 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16893618 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16893618 | lifeskim:mentions | umls-concept:C0036770 | lld:lifeskim |
| pubmed-article:16893618 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16893618 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16893618 | lifeskim:mentions | umls-concept:C1258354 | lld:lifeskim |
| pubmed-article:16893618 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16893618 | pubmed:dateCreated | 2006-9-1 | lld:pubmed |
| pubmed-article:16893618 | pubmed:abstractText | In this study, the effects of 4-tert-octylphenol (OP) were examined on the viability of rat cultured Sertoli cells using the MTT assay and OP-induced apoptosis was detected by transmission electron microscope (TEM), flow cytometric analysis and Hoechst staining. In addition, RT-PCR was used to analyze the levels of Bcl-2 and Bax mRNA. Bcl-2, Bax and caspase-3 protein expressions were determined by Western blot analysis. Sertoli cells were treated with OP from 30 to 60microM for 6-24h. Decreased viability of Sertoli cells and increased apoptosis occurred in a concentration- and a time-dependent manner. The expression of Bcl-2 was down-regulated, while the expression of Bax up-regulated. OP also down-regulated the expression of 32kDa procaspase-3, which was cleaved to generate active subunit (17kDa). These results suggest that OP may induce Sertoli cell apoptosis by regulation of Bcl-2/Bax and caspase-3 activation. | lld:pubmed |
| pubmed-article:16893618 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16893618 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893618 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16893618 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16893618 | pubmed:issn | 0378-4274 | lld:pubmed |
| pubmed-article:16893618 | pubmed:author | pubmed-author:SongLingL | lld:pubmed |
| pubmed-article:16893618 | pubmed:author | pubmed-author:QianJieJ | lld:pubmed |
| pubmed-article:16893618 | pubmed:author | pubmed-author:WangXinruX | lld:pubmed |
| pubmed-article:16893618 | pubmed:author | pubmed-author:ChenJianfengJ | lld:pubmed |
| pubmed-article:16893618 | pubmed:author | pubmed-author:BianQianQ | lld:pubmed |
| pubmed-article:16893618 | pubmed:author | pubmed-author:CuiLunbiaoL | lld:pubmed |
| pubmed-article:16893618 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16893618 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:16893618 | pubmed:volume | 166 | lld:pubmed |
| pubmed-article:16893618 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16893618 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16893618 | pubmed:pagination | 178-86 | lld:pubmed |
| pubmed-article:16893618 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16893618 | pubmed:meshHeading | pubmed-meshheading:16893618... | lld:pubmed |
| pubmed-article:16893618 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16893618 | pubmed:articleTitle | Octylphenol induces apoptosis in cultured rat Sertoli cells. | lld:pubmed |
| pubmed-article:16893618 | pubmed:affiliation | Key Laboratory of Reproductive Medicine of Jiangsu Province, Nanjing Medical University, Nanjing 210029, China. | lld:pubmed |
| pubmed-article:16893618 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16893618 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16893618 | lld:pubmed |
