Linked Life Data

1689349

Source:http://linkedlifedata.com/resource/pubmed/id/1689349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-3-23
pubmed:abstractText
S-Antigen (S-Ag) is a well characterized 45,000 m.w. photoreceptor cell protein. When injected into susceptible animal species, including primates, it induces an experimental autoimmune uveitis, a predominantly T cell-mediated autoimmune disease of the retina and uveal tract of the eye, and of the pineal gland. In this study we found an amino acid sequence homology between a uveitopathogenic site of S-Ag, several viral proteins and one additional nonviral protein. An experimental autoimmune uveitis and pinealitis was induced in Lewis rats with these different synthetic peptides, corresponding to the amino sequence of hepatitis B virus DNA polymerase, gag-pol polyprotein of Baboon endogenous virus and gag-pol polyprotein of AKV murine leukemia virus and potato proteinase inhibitor IIa, which contain three or more consecutive amino acids identical to peptide M in S-Ag. Lymph node cells from rats immunized with either peptide M or the different synthetic peptides showed a significant degree of cross-reaction. Mononuclear cells from monkeys (Macaca fascicularis) immunized with peptide M also showed significant proliferation when incubated with either peptide M or synthetic peptides as measured by in vitro lymphocyte mitogenesis assay using [3H]TdR. Based on our findings we conclude that a viral infection may sensitize the mononuclear cells that can cross-react with self proteins by a mechanism termed molecular mimicry. Tissue injury from the resultant autoantigenic event can take place in the absence of the infectious virus that initiated the immune response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1282-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1689349-Amino Acid Sequence, pubmed-meshheading:1689349-Animals, pubmed-meshheading:1689349-Antigens, pubmed-meshheading:1689349-Arrestin, pubmed-meshheading:1689349-Autoantigens, pubmed-meshheading:1689349-Autoimmune Diseases, pubmed-meshheading:1689349-Cross Reactions, pubmed-meshheading:1689349-DNA-Directed DNA Polymerase, pubmed-meshheading:1689349-Epitopes, pubmed-meshheading:1689349-Eye Proteins, pubmed-meshheading:1689349-Fusion Proteins, gag-pol, pubmed-meshheading:1689349-Gene Products, gag, pubmed-meshheading:1689349-Lymph Nodes, pubmed-meshheading:1689349-Lymphocyte Activation, pubmed-meshheading:1689349-Molecular Sequence Data, pubmed-meshheading:1689349-Oligopeptides, pubmed-meshheading:1689349-Pineal Gland, pubmed-meshheading:1689349-Protease Inhibitors, pubmed-meshheading:1689349-Rats, pubmed-meshheading:1689349-Rats, Inbred Lew, pubmed-meshheading:1689349-Uveitis
pubmed:year
1990
pubmed:articleTitle
Molecular mimicry between a uveitopathogenic site of S-antigen and viral peptides. Induction of experimental autoimmune uveitis in Lewis rats.
pubmed:affiliation
Molecular Biology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.