| pubmed-article:16893479 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16893479 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:16893479 | lifeskim:mentions | umls-concept:C0344315 | lld:lifeskim |
| pubmed-article:16893479 | lifeskim:mentions | umls-concept:C0289174 | lld:lifeskim |
| pubmed-article:16893479 | lifeskim:mentions | umls-concept:C0038663 | lld:lifeskim |
| pubmed-article:16893479 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16893479 | pubmed:dateCreated | 2007-5-17 | lld:pubmed |
| pubmed-article:16893479 | pubmed:abstractText | In depressed patients, high-lethality suicidal acts are accompanied by serotonin system abnormalities analogous to those seen in completed suicides. We have previously reported greater platelet 5-HT2A receptor density, and impaired serotonin enhancement of ADP-induced platelet aggregation, an indirect measure of signal transduction, in high-lethality suicide attempters. We hypothesized that serotonin-activated phosphoinositide (PI) hydrolysis, a direct measure of platelet serotonin 5-HT2A receptor responsivity would be lower in depressed high-lethality suicide attempters. Twenty-three depressed in-patients that had previously made suicide attempts (low-lethality, n=6; high-lethality, n=17) had platelet 5-HT2A-mediated serotonin-simulated PI hydrolysis assayed. Platelet 5-HT2A receptor responsivity in high-lethality suicide attempters was 41% that of low-lethality suicide attempters (p<0.05). A seasonal effect was also observed. High-lethality suicidal acts are associated with more 5-HT2A receptors but impaired signal transduction. | lld:pubmed |
| pubmed-article:16893479 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893479 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893479 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16893479 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893479 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16893479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16893479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893479 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16893479 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16893479 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16893479 | pubmed:issn | 1461-1457 | lld:pubmed |
| pubmed-article:16893479 | pubmed:author | pubmed-author:MaloneKevin... | lld:pubmed |
| pubmed-article:16893479 | pubmed:author | pubmed-author:EllisSteven... | lld:pubmed |
| pubmed-article:16893479 | pubmed:author | pubmed-author:John MannJJ | lld:pubmed |
| pubmed-article:16893479 | pubmed:author | pubmed-author:CurrierDianne... | lld:pubmed |
| pubmed-article:16893479 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16893479 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:16893479 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16893479 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16893479 | pubmed:pagination | 335-43 | lld:pubmed |
| pubmed-article:16893479 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:16893479 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:16893479 | pubmed:articleTitle | Platelet 5-HT2A receptor subresponsivity and lethality of attempted suicide in depressed in-patients. | lld:pubmed |
| pubmed-article:16893479 | pubmed:affiliation | Department of Psychiatry, Columbia University, New York, NY, USA. | lld:pubmed |
| pubmed-article:16893479 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16893479 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16893479 | lld:pubmed |
