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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-5-17
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pubmed:abstractText |
In depressed patients, high-lethality suicidal acts are accompanied by serotonin system abnormalities analogous to those seen in completed suicides. We have previously reported greater platelet 5-HT2A receptor density, and impaired serotonin enhancement of ADP-induced platelet aggregation, an indirect measure of signal transduction, in high-lethality suicide attempters. We hypothesized that serotonin-activated phosphoinositide (PI) hydrolysis, a direct measure of platelet serotonin 5-HT2A receptor responsivity would be lower in depressed high-lethality suicide attempters. Twenty-three depressed in-patients that had previously made suicide attempts (low-lethality, n=6; high-lethality, n=17) had platelet 5-HT2A-mediated serotonin-simulated PI hydrolysis assayed. Platelet 5-HT2A receptor responsivity in high-lethality suicide attempters was 41% that of low-lethality suicide attempters (p<0.05). A seasonal effect was also observed. High-lethality suicidal acts are associated with more 5-HT2A receptors but impaired signal transduction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1461-1457
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-43
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16893479-Adolescent,
pubmed-meshheading:16893479-Adrenergic alpha-Agonists,
pubmed-meshheading:16893479-Adult,
pubmed-meshheading:16893479-Aged,
pubmed-meshheading:16893479-Aged, 80 and over,
pubmed-meshheading:16893479-Aging,
pubmed-meshheading:16893479-Blood Platelets,
pubmed-meshheading:16893479-Data Interpretation, Statistical,
pubmed-meshheading:16893479-Depressive Disorder, Major,
pubmed-meshheading:16893479-Epinephrine,
pubmed-meshheading:16893479-Female,
pubmed-meshheading:16893479-Humans,
pubmed-meshheading:16893479-Inpatients,
pubmed-meshheading:16893479-Longitudinal Studies,
pubmed-meshheading:16893479-Male,
pubmed-meshheading:16893479-Middle Aged,
pubmed-meshheading:16893479-Phosphatidylinositols,
pubmed-meshheading:16893479-Prefrontal Cortex,
pubmed-meshheading:16893479-Psychiatric Status Rating Scales,
pubmed-meshheading:16893479-RNA, Messenger,
pubmed-meshheading:16893479-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:16893479-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:16893479-Seasons,
pubmed-meshheading:16893479-Second Messenger Systems,
pubmed-meshheading:16893479-Signal Transduction,
pubmed-meshheading:16893479-Suicide,
pubmed-meshheading:16893479-Suicide, Attempted
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pubmed:year |
2007
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pubmed:articleTitle |
Platelet 5-HT2A receptor subresponsivity and lethality of attempted suicide in depressed in-patients.
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pubmed:affiliation |
Department of Psychiatry, Columbia University, New York, NY, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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