Source:http://linkedlifedata.com/resource/pubmed/id/16892550
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2006-8-8
|
| pubmed:abstractText |
Most gastrointestinal stromal tumors (GISTs) carry gain-of-function mutations of the KIT gene encoding the receptor tyrosine kinase KIT. However, in a subset of GISTs no activating mutations are detectable in KIT. Recently, PDGFRalpha mutations have been identified as alternative oncogenic mechanism. We studied a panel of 100 GISTs for mutations in hot spot regions of KIT (exons 9, 11, 13 and 17) and PDGFRalpha (exons 12 and 18) and compared the results with pathomorphological and immunohistochemical data.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0070-4113
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
174-83
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:16892550-Diagnosis, Differential,
pubmed-meshheading:16892550-Gastrointestinal Stromal Tumors,
pubmed-meshheading:16892550-Humans,
pubmed-meshheading:16892550-Mutation,
pubmed-meshheading:16892550-Phenotype,
pubmed-meshheading:16892550-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:16892550-Receptor, Platelet-Derived Growth Factor alpha,
pubmed-meshheading:16892550-Stomach Neoplasms
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
[Gastrointestinal stromal tumors carrying PDGFRalpha mutations occur preferentially in the stomach and exhibit an epithelioid or mixed phenotype].
|
| pubmed:affiliation |
Institut für Pathologie, Universitäitsklinikum Bonn.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|