Linked Life Data

16891200

Source:http://linkedlifedata.com/resource/pubmed/id/16891200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-8-7
pubmed:abstractText
Bone marrow angiogenesis in patients with idiopathic myelofibrosis (IM) was evaluated by using a quantitative morphometric analysis test system. IM specimens had a significantly higher degree of bone marrow microvessel density (MVD) compared with control specimens. The higher degree of angiogenesis was associated with increased expression of basic fibroblast growth factor in megakaryocytes and endothelial cells in the IM bone marrow specimens. Increased vascular endothelial growth factor expression was seen in some cases of the prefibrotic form of IM. Morphometric quantitative measurements revealed that the MVD was reduced progressively in 4 cases of IM after allogeneic stem cell transplantation. These findings suggest that angiogenesis likely has an important role in the pathogenesis of IM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-9173
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Quantitative evaluation of bone marrow angiogenesis in idiopathic myelofibrosis.
pubmed:affiliation
Department of Pathology, Section of Hematology/Oncology, University of Illinois Cancer Center, University of Illinois College of Medicine, Chicago, IL, USA.
pubmed:publicationType
Journal Article