| pubmed-article:16891117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C0291573 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C0022115 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C2347885 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16891117 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16891117 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:16891117 | pubmed:dateCreated | 2006-8-25 | lld:pubmed |
| pubmed-article:16891117 | pubmed:abstractText | A non-peptide-based isatin sulfonamide analog, WC-II-89, was synthesized and its inhibition toward recombinant human caspase-3 and other caspases was determined. This compound showed high potency for inhibiting caspase-3 and -7, and high selectivity against caspases-1, -6, and -8. [(18)F]WC-II-89 was synthesized via a nucleophilic substitution of the corresponding mesylate precursor in high yield and radiochemical purity. Biodistribution studies using [(18)F]WC-II-89 revealed higher uptake in liver and spleen of cycloheximide-treated rats, an animal model of apoptosis, relative to control animals. Western blot analysis confirmed the presence of activated caspase-3 in the liver and spleen of cycloheximide-treated animals. MicroPET imaging studies revealed a high uptake of the radiotracer in the liver of a cycloheximide-treated rat relative to the untreated control. These data suggest that [(18)F]WC-II-89 is a potential radiotracer for imaging caspase-3 activation in tissues undergoing apoptosis. | lld:pubmed |
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| pubmed-article:16891117 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16891117 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16891117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16891117 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16891117 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:WelchMichael... | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:MachRobert... | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:ZhouDongD | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:XuJinbinJ | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:JonesLynneL | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:ZengChenboC | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:ChuWenhuaW | lld:pubmed |
| pubmed-article:16891117 | pubmed:author | pubmed-author:RothfussJusti... | lld:pubmed |
| pubmed-article:16891117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16891117 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16891117 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16891117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16891117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16891117 | pubmed:pagination | 5041-6 | lld:pubmed |
| pubmed-article:16891117 | pubmed:dateRevised | 2010-4-12 | lld:pubmed |
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| pubmed-article:16891117 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16891117 | pubmed:articleTitle | Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. | lld:pubmed |
| pubmed-article:16891117 | pubmed:affiliation | Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:16891117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16891117 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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