Source:http://linkedlifedata.com/resource/pubmed/id/16889962
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
20
|
| pubmed:dateCreated |
2006-9-11
|
| pubmed:abstractText |
The in vitro activity of newly synthesized bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes and bis-(chlorophenyl)-bicyclo[2.2.2]octanes against Plasmodium falciparum K(1) (resistant to chloroquine and pyrimethamine) and Trypanosoma brucei rhodesiense was investigated. Especially the bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes exhibit promising antitrypanosomal activity and were tested in vivo against Trypanosoma brucei brucei featuring moderate activities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5457-61
|
| pubmed:meshHeading |
pubmed-meshheading:16889962-Animals,
pubmed-meshheading:16889962-Antiprotozoal Agents,
pubmed-meshheading:16889962-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:16889962-Molecular Structure,
pubmed-meshheading:16889962-Parasitic Sensitivity Tests,
pubmed-meshheading:16889962-Plasmodium falciparum,
pubmed-meshheading:16889962-Stereoisomerism,
pubmed-meshheading:16889962-Structure-Activity Relationship,
pubmed-meshheading:16889962-Trypanosoma brucei brucei,
pubmed-meshheading:16889962-Trypanosoma brucei rhodesiense
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes.
|
| pubmed:affiliation |
Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University, Universitätsplatz 1, A-8010 Graz, Austria.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|