Source:http://linkedlifedata.com/resource/pubmed/id/16889774
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-11-27
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| pubmed:abstractText |
C57BL/10ScCr mice, lack Toll-like receptor 4 and a functional Interleukin-12 receptor. Taking this into account, susceptibility of these mice to Neospora caninum infection was assessed comparatively to that of immunocompetent C57BL/10ScSn mice. C57BL/10ScCr mice inoculated intraperitoneally with 5x10(5)N. caninum tachyzoites showed a high susceptibility to this parasite. All infected C57BL/10ScCr mice were dead by day 8 post-infection whereas all control C57BL/10ScSn mice survived this parasitic challenge. Immunohistochemical analysis of infected C57BL/10ScCr mice showed N. caninum tachyzoites spread in the pancreas, liver, lung, intestine, heart and brain whereas no parasites were detected in similarly infected C57BL/10ScSn controls. The higher susceptibility of C57BL/10ScCr mice to neosporosis correlates with reduced interferon-gamma mRNA expression and increased IL-4 mRNA expression, comparatively to C57BL/10ScSn controls, detected in the spleen after the parasitic challenge. C57BL/10ScCr mice could thus be used as a new experimental model where to study immunobiological mechanisms associated with host susceptibility to neosporosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0014-4894
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
115
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
68-75
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16889774-Animals,
pubmed-meshheading:16889774-Brain,
pubmed-meshheading:16889774-Coccidiosis,
pubmed-meshheading:16889774-DNA, Protozoan,
pubmed-meshheading:16889774-Disease Models, Animal,
pubmed-meshheading:16889774-Disease Susceptibility,
pubmed-meshheading:16889774-Immunity, Cellular,
pubmed-meshheading:16889774-Immunocompetence,
pubmed-meshheading:16889774-Immunohistochemistry,
pubmed-meshheading:16889774-Interferon-gamma,
pubmed-meshheading:16889774-Interleukin-4,
pubmed-meshheading:16889774-Male,
pubmed-meshheading:16889774-Mice,
pubmed-meshheading:16889774-Mice, Inbred C57BL,
pubmed-meshheading:16889774-Neospora,
pubmed-meshheading:16889774-Polymerase Chain Reaction,
pubmed-meshheading:16889774-RNA, Messenger,
pubmed-meshheading:16889774-Receptors, Interleukin-12,
pubmed-meshheading:16889774-Toll-Like Receptor 4,
pubmed-meshheading:16889774-Viscera
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| pubmed:year |
2007
|
| pubmed:articleTitle |
Neospora caninum: high susceptibility to the parasite in C57BL/10ScCr mice.
|
| pubmed:affiliation |
ICBAS--Instituto de Ciências Biomédicas de Abel Salazar, Largo do Professor Abel Salazar 2, 4099-003, Porto, Portugal.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|