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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2006-8-25
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pubmed:abstractText |
Melanin-concentrating hormone (MCH) is a cyclic 19 amino acid orexigenic neuropeptide. The action of MCH on feeding is thought to involve the activation of its respective G protein-coupled receptor MCH-R1. Consequently, antagonists that block MCH regulated MCH-R1 activity may provide a viable approach to the treatment of diet-induced obesity. This communication reports the discovery of a novel MCH-R1 receptor antagonist, the biarylether 7, identified through high throughput screening. The solid-phase synthesis and structure-activity relationship of related analogs is described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5066-72
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pubmed:meshHeading |
pubmed-meshheading:16887348-Combinatorial Chemistry Techniques,
pubmed-meshheading:16887348-Drug Evaluation, Preclinical,
pubmed-meshheading:16887348-Ethers,
pubmed-meshheading:16887348-Humans,
pubmed-meshheading:16887348-Inhibitory Concentration 50,
pubmed-meshheading:16887348-Obesity,
pubmed-meshheading:16887348-Receptors, Pituitary Hormone,
pubmed-meshheading:16887348-Receptors, Somatostatin,
pubmed-meshheading:16887348-Structure-Activity Relationship
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pubmed:year |
2006
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pubmed:articleTitle |
Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.
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pubmed:affiliation |
Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. vma@amgen.com
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pubmed:publicationType |
Journal Article
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