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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-8-4
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pubmed:abstractText |
The cochlear microphonic is a receptor potential believed to be generated primarily by outer hair cells. Its detection in surface recordings has been considered a distinctive sign of outer hair cell integrity in patients with auditory neuropathy. This report focuses on the results of an analysis performed on cochlear microphonic recorded by transtympanic electrocochleography in response to clicks in 502 subjects with normal hearing threshold or various degrees of hearing impairment, and in 20 patients with auditory neuropathy. Cochlear microphonics recorded in normally-hearing and hearing-impaired ears showed amplitudes decreasing by the elevation of compound action potential Cochlear microphonic responses were clearly detected in ears with profound hearing loss. After separating recordings according to the presence or absence of central nervous system pathology (CNS+ and CNS-, respectively), cochlear microphonic amplitude was significantly higher in CNS+ than in CNS- subjects with normally-hearing ears and at 70 dB nHL compound action potential threshold. Cochlear microphonic responses were detected in all auditory neuropathy patients, with similar amplitudes and thresholds to those calculated for normally-hearing CNS- subjects. Cochlear microphonic duration was significantly higher in auditory neuropathy and normally-hearing CNS+ patients compared to CNS- subjects. Our results show that: 1. cochlear microphonic detection is not a distinctive feature of auditory neuropathy; 2. CNS+ subjects showed enhancement in cochlear microphonic amplitude and duration, possibly due to efferent system dysfunction; 3. long-lasting, high frequency cochlear microphonics with amplitudes comparable to those obtained from CNS- ears were found in auditory neuropathy patients. This could result from a variable combination of afferent compartment lesion, efferent system dysfacilitation and loss of outer hair cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16886850-10386850,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16886850-9796644
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0392-100X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
78-95
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
pubmed-meshheading:16886850-Adolescent,
pubmed-meshheading:16886850-Adult,
pubmed-meshheading:16886850-Audiometry, Evoked Response,
pubmed-meshheading:16886850-Child,
pubmed-meshheading:16886850-Child, Preschool,
pubmed-meshheading:16886850-Cochlear Microphonic Potentials,
pubmed-meshheading:16886850-Female,
pubmed-meshheading:16886850-Hair Cells, Auditory, Outer,
pubmed-meshheading:16886850-Hearing,
pubmed-meshheading:16886850-Hearing Loss, Sensorineural,
pubmed-meshheading:16886850-Humans,
pubmed-meshheading:16886850-Infant,
pubmed-meshheading:16886850-Male,
pubmed-meshheading:16886850-Middle Aged,
pubmed-meshheading:16886850-Otoacoustic Emissions, Spontaneous,
pubmed-meshheading:16886850-Severity of Illness Index,
pubmed-meshheading:16886850-Tympanic Membrane
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pubmed:year |
2006
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pubmed:articleTitle |
Cochlear microphonic potential recorded by transtympanic electrocochleography in normally-hearing and hearing-impaired ears.
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pubmed:affiliation |
Department of Medical and Surgical Specialities, Audiology and Phoniatric Service, University of Padua, Italy. rosamaria.santarelli@unipd.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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