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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-28
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pubmed:abstractText |
Injury to the renal microvasculature may be a major factor in the progression of renal disease; therefore, protection of endothelial cells (EC) in renal vasculature may have a therapeutic role in renal fibrosis. Recently, a soluble, stable, and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, was developed. The contribution of COMP-Ang1 in renal interstitial fibrosis, however, remains to be clarified. This study investigated the effects of COMP-Ang1 on peritubular capillary EC in the renal cortex and the renal fibrogenic process that is triggered by unilateral ureteral obstruction. COMP-Ang1 preserved renal platelet-EC adhesion molecule-1-and Tie2-positive EC. Morphologic examination indicated less tubular injury and tubulointerstitial fibrosis in mice that received COMP-Ang1 than vehicle-treated mice. Interstitial type I collagen and myofibroblast accumulation were significantly suppressed by COMP-Ang1 treatment. COMP-Ang1 increased Tie2 and Akt phosphorylation in ureteral obstructed kidneys. Renal surface microvasculature and renal blood flow were higher after treatment with COMP-Ang1 than with vehicle. COMP-Ang1 treatment decreased monocyte/macrophage infiltration, tissue levels of TGF-beta1, and Smad 2/3 phosphorylation and increased Smad 7 in the obstructed kidney. These results demonstrate that COMP-Ang1 treatment can decrease the progression of renal fibrosis in unilateral ureteral obstruction. COMP-Ang1 may be an endothelium-specific therapeutic modality in fibrotic renal disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/COMP-Ang1 fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, TIE-2,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Smad7 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/cartilage matrix protein,
http://linkedlifedata.com/resource/pubmed/chemical/monocyte-macrophage...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1046-6673
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pubmed:author |
pubmed-author:ChoChung-HyunCH,
pubmed-author:ChoiKyu-SilKS,
pubmed-author:JangKyu YunKY,
pubmed-author:KangKyung PyoKP,
pubmed-author:KimDuk HoonDH,
pubmed-author:KimWonW,
pubmed-author:KohGou YoungGY,
pubmed-author:LUOW HWH,
pubmed-author:LeeSang YongSY,
pubmed-author:MoonSang-OkSO,
pubmed-author:ParkSung KwangSK,
pubmed-author:SungMi JeongMJ,
pubmed-author:YoonKwon-HaKH
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2474-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16885409-Angiopoietin-1,
pubmed-meshheading:16885409-Animals,
pubmed-meshheading:16885409-Antigens, CD31,
pubmed-meshheading:16885409-Antigens, Differentiation,
pubmed-meshheading:16885409-Blood Flow Velocity,
pubmed-meshheading:16885409-Endothelial Cells,
pubmed-meshheading:16885409-Extracellular Matrix Proteins,
pubmed-meshheading:16885409-Fibrosis,
pubmed-meshheading:16885409-Glycoproteins,
pubmed-meshheading:16885409-Kidney,
pubmed-meshheading:16885409-Male,
pubmed-meshheading:16885409-Mice,
pubmed-meshheading:16885409-Microcirculation,
pubmed-meshheading:16885409-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:16885409-Receptor, TIE-2,
pubmed-meshheading:16885409-Recombinant Fusion Proteins,
pubmed-meshheading:16885409-Renal Artery,
pubmed-meshheading:16885409-Smad2 Protein,
pubmed-meshheading:16885409-Smad3 Protein,
pubmed-meshheading:16885409-Smad7 Protein,
pubmed-meshheading:16885409-Transforming Growth Factor beta1,
pubmed-meshheading:16885409-Ureteral Obstruction
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pubmed:year |
2006
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pubmed:articleTitle |
COMP-angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction model.
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pubmed:affiliation |
Renal Regeneration Laboratory and Department of Internal Medicine, Chonbuk National University Medical School, San 2-20 Keumam-dong, Jeonju, 561-180, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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