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rdf:type |
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lifeskim:mentions |
umls-concept:C0010031,
umls-concept:C0021743,
umls-concept:C0086982,
umls-concept:C0205263,
umls-concept:C0205266,
umls-concept:C0206679,
umls-concept:C1332821,
umls-concept:C1367714,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-10-2
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pubmed:abstractText |
Herpes simplex virus type 1 ocular infection elicits a potent inflammatory response including the production of the chemokines, CXCL9 and CXCL10, in mice. Since HSV-1 nucleic acid is recognized by pattern receptors including Toll-like receptor (TLR) 9, we tested the hypothesis that TLR9 is necessary for the early augmentation of CXCL10 following HSV-1 infection. Similar to wild type controls, TLR9 deficient mice constitutively expressed CXCL10 in the cornea. Following infection or stimulation with the deoxycytidylate-phosphate-deoxyguanylate (CpG) motif, CXCL10 levels were significantly elevated in the cornea of wild type but not TLR9 or type I interferon receptor deficient mice. The reduced CXCL10 response in the cornea of TLR deficient mice was correlative with an increase in virus shedding and a reduction in neutrophil infiltration. This is the first report that shows enhanced CXCL10 expression following neurotropic viral replication requires both intact TLR 9 and type I interferon signaling pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-10786993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-11040085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-11130078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-12050368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-12885911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-12941914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-14563635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-15145317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-15272082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-15499542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-15671286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-16177121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-16377001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-16424890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-16476970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-1649322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16884784-16570856
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-52
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16884784-Animals,
pubmed-meshheading:16884784-Cercopithecus aethiops,
pubmed-meshheading:16884784-Chemokine CXCL10,
pubmed-meshheading:16884784-Chemokine CXCL9,
pubmed-meshheading:16884784-Chemokines, CXC,
pubmed-meshheading:16884784-Female,
pubmed-meshheading:16884784-Herpesvirus 1, Human,
pubmed-meshheading:16884784-Interferon Type I,
pubmed-meshheading:16884784-Keratitis, Herpetic,
pubmed-meshheading:16884784-Male,
pubmed-meshheading:16884784-Mice,
pubmed-meshheading:16884784-Mice, Inbred C57BL,
pubmed-meshheading:16884784-Mice, Knockout,
pubmed-meshheading:16884784-Microscopy, Confocal,
pubmed-meshheading:16884784-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16884784-Signal Transduction,
pubmed-meshheading:16884784-Toll-Like Receptor 9,
pubmed-meshheading:16884784-Vero Cells
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pubmed:year |
2006
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pubmed:articleTitle |
Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. todd-wuest@ouhsc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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