Source:http://linkedlifedata.com/resource/pubmed/id/16884691
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2006-8-14
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pubmed:abstractText |
The cytogenetic hallmark of myxoid type and round cell type liposarcoma consists of reciprocal translocation of t(12;16)(q13;p11) and t(12;22)(q13;q12), which results in fusion of TLS/FUS and CHOP, and EWS and CHOP, respectively. Nine structural variations of the TLS/FUS-CHOP chimeric transcript have been reported, however, only two types of EWS-CHOP have been described. We describe here a case of myxoid liposarcoma containing a novel EWS-CHOP chimeric transcript and identified the breakpoint occurring in intron 13 of EWS. Reverse transcription-polymerase chain reaction and direct sequence showed that exon 13 of EWS was in-frame fused to exon 2 of CHOP. Genomic analysis revealed that the breaks were located in intron 13 of EWS and intron 1 of CHOP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
348
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
437-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16884691-Adult,
pubmed-meshheading:16884691-Base Sequence,
pubmed-meshheading:16884691-Chimera,
pubmed-meshheading:16884691-Female,
pubmed-meshheading:16884691-Gene Fusion,
pubmed-meshheading:16884691-Humans,
pubmed-meshheading:16884691-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16884691-Liposarcoma, Myxoid,
pubmed-meshheading:16884691-Molecular Sequence Data,
pubmed-meshheading:16884691-RNA-Binding Protein EWS,
pubmed-meshheading:16884691-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16884691-Transcription Factor CHOP
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pubmed:year |
2006
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pubmed:articleTitle |
A novel type of EWS-CHOP fusion gene in myxoid liposarcoma.
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pubmed:affiliation |
Department of Orthopaedics, Osaka University Graduate School of Medicine, Japan. ymatsui@sb4.so-net.ne.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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