| pubmed-article:16883311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0218633 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0010583 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0210630 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0445550 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C0332257 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C1512335 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C1300564 | lld:lifeskim |
| pubmed-article:16883311 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16883311 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16883311 | pubmed:dateCreated | 2006-8-2 | lld:pubmed |
| pubmed-article:16883311 | pubmed:abstractText | The use of a combination of G-CSF and GM-CSF versus G-CSF alone, after cyclophosphamide (4 g/m2) was compared in two randomized phase III studies, including 120 patients. In study A, 60 patients received 5 x 2 microg/kg/day of G-CSF and GM-CSF compared to 5 mug/kg/day of G-CSF. In study B, 60 patients received 2.5 x 2 microg/kg/day G-CSF and GM-CSF compared to G-CSF alone (5 microg/kg/day). With the aim to collect at least 5 x 10(6)/kg CD34 cells in a maximum of three large volume leukapherises (LK), 123 LK were performed in study A, showing a significantly higher number of patients reaching 10 x 10(6)/kg CD34 cells (21/29 in G+GM-CSF arm vs 11/27 in G-CSF arm, P=0.00006). In study B, 109 LK were performed, with similar results (10/27 vs 15/26, P=0.003). In both the study, the total harvest of CD34 cells/kg was twofold higher in G-CSF plus GM-CSF group (18.3 x 10(6) in study A and 15.85 x 10(6) in study B) than in G-CSF group (9 x 10(6) in study A and 8.1 x 10(6) in study B), a significant difference only seen in multiple myeloma, with no significant difference in terms of mobilized myeloma cells between G-CSF and GM-CSF groups. | lld:pubmed |
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| pubmed-article:16883311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16883311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16883311 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16883311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16883311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16883311 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16883311 | pubmed:issn | 0268-3369 | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:KleinBB | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:LopezEE | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:ExbrayatCC | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:LuZ YZY | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:RossiJ FJF | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:DauresJ PJP | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:FegueuxNN | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:CeballosPP | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:QuittetPP | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:LatryPP | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:LegouffeEE | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:PouesselDD | lld:pubmed |
| pubmed-article:16883311 | pubmed:author | pubmed-author:RouilléVV | lld:pubmed |
