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rdf:type |
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lifeskim:mentions |
umls-concept:C0003968,
umls-concept:C0011177,
umls-concept:C0023775,
umls-concept:C0038454,
umls-concept:C0178602,
umls-concept:C0205217,
umls-concept:C0228174,
umls-concept:C0348016,
umls-concept:C0376259,
umls-concept:C0591833,
umls-concept:C1707520
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pubmed:issue |
2
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pubmed:dateCreated |
2006-8-2
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pubmed:abstractText |
Oxidative damage has been implicated in the pathogenesis of cerebral ischemia. We previously demonstrated that exogenously supplied dehydroascorbic acid (DHA), an oxidized, blood-brain barrier transportable form of the antioxidant ascorbic acid (AA), improves outcome after experimental stroke.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4040
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-8; discussion 383-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16883179-Animals,
pubmed-meshheading:16883179-Antioxidants,
pubmed-meshheading:16883179-Ascorbic Acid,
pubmed-meshheading:16883179-Brain Ischemia,
pubmed-meshheading:16883179-Cerebral Cortex,
pubmed-meshheading:16883179-Cerebral Infarction,
pubmed-meshheading:16883179-Citric Acid,
pubmed-meshheading:16883179-Dehydroascorbic Acid,
pubmed-meshheading:16883179-Disease Models, Animal,
pubmed-meshheading:16883179-Excipients,
pubmed-meshheading:16883179-Infarction, Middle Cerebral Artery,
pubmed-meshheading:16883179-Injections, Intravenous,
pubmed-meshheading:16883179-Lipid Peroxidation,
pubmed-meshheading:16883179-Mice,
pubmed-meshheading:16883179-Mice, Inbred C57BL,
pubmed-meshheading:16883179-Nerve Degeneration,
pubmed-meshheading:16883179-Neuroprotective Agents,
pubmed-meshheading:16883179-Oxidative Stress,
pubmed-meshheading:16883179-Reperfusion Injury,
pubmed-meshheading:16883179-Sorbitol,
pubmed-meshheading:16883179-Treatment Outcome,
pubmed-meshheading:16883179-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
A cerebroprotective dose of intravenous citrate/sorbitol-stabilized dehydroascorbic acid is correlated with increased cerebral ascorbic acid and inhibited lipid peroxidation after murine reperfused stroke.
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pubmed:affiliation |
Department of Neurological Surgery, College of Physicians & Surgeons, Columbia University, New York, New York 10032, USA. wjm32@columbia.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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