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pubmed-article:16883006pubmed:abstractTextIdiopathic pulmonary fibrosis (IPF) is characterized by an uncontrolled accumulation and activation of lung fibroblasts. A modulation of fibroblast activation has been observed in various systems with octreotide, a synthetic somatostatin analog with strong affinity for the somatostatin receptor subtype 2 (sst2). One aim of our study was to evaluate the expression of somatostatin receptors in the lungs of patients with IPF. A second aim was to evaluate the relationship between 111In-octreotide uptake and the effect of pulmonary fibrosis as assessed by lung function tests and parameters and by radiologic findings.lld:pubmed
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pubmed-article:16883006pubmed:articleTitleIncreased uptake of 111In-octreotide in idiopathic pulmonary fibrosis.lld:pubmed
pubmed-article:16883006pubmed:affiliationDepartment of Nuclear Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France. rachida.lebtahi@bch.aphp.frlld:pubmed
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