Linked Life Data

1688254

Source:http://linkedlifedata.com/resource/pubmed/id/1688254

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-12
pubmed:dateCreated
1993-6-10
pubmed:abstractText
The division of T cells into distinct subsets (Th-1 and Th-2), based upon cytokine production, is a major advance in understanding the immune reactivities particularly those associated with allergy. This report summarizes some of the highlights on pathogenesis of allergic rhinitis. Th-2 cells, driven by IL-4, play an important role in allergic reactions inducing IgE switching in B cells and proliferation of mastocytes. In addition, by interaction with IL-5, Th-2 lymphocytes promotes eosinophil growth. By contrast, Th-1 cells antagonize Th-2 activity by IFN-gamma production. Finally IL-10, produced by Th-2, blocks the effects of the cytokines elaborated by Th-1. Recent results of this rapidly expanding area of research provide the background for this review. The intricate connections between Th-1, Th-2, the endothelial cells of the nose vessels and stromal cells are discussed.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0390-5462
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-24
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[New perspectives on the pathogenesis of rhinitis].
pubmed:affiliation
Istituto Policattedra di Clinica Otorinolaringoiatrica dell'Università di Torino.
pubmed:publicationType
Journal Article, English Abstract, Review