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rdf:type |
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0183683,
umls-concept:C0254610,
umls-concept:C0344211,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1332717,
umls-concept:C1367389,
umls-concept:C1413244,
umls-concept:C1515021,
umls-concept:C1521721,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
32
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pubmed:dateCreated |
2006-8-9
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pubmed:abstractText |
CD8(+) T cells are commonly divided into naïve CD44(lo)CD122(lo) and "memory phenotype" CD44(hi)CD122(hi) cells. Here we show data suggesting that these two cell populations represent independent CD8(+) T cell subsets. Whereas IL-15(-/-) mice lack CD44(hi)CD122(hi) CD8(+) T cells, mice deficient in the kinase ITK lack CD44(lo)CD122(lo) cells among CD8(+) T cells. The same defects were observed during thymus development. CD44(hi)CD122(hi) cells were found among double-positive thymocytes and increased in frequency during CD8 development in wild-type mice. At the mature stage, IL-15(-/-) mice harbored virtually no CD44(hi)CD122(hi) CD8(+) thymocytes. In contrast, ITK(-/-) mice lacked CD44(lo)CD122(lo) CD8(+) cells at this stage. We generated mice with genetic deletions in both IL-15 and ITK and observed a severe reduction of all CD8(+) T cells. The two CD44(lo)CD122(lo) and CD44(hi)CD122(hi) CD8(+) T cell subsets differed in the periphery in that natural killer (NK) receptor expression was found only on CD44(hi)CD122(hi) CD8(+) T cells. This expression was paralleled by their ability to respond to both T cell receptor and NK receptor engagements. In contrast, CD44(lo)CD122(lo) CD8(+) T cells mounted stronger responses to T cell receptor stimulation but failed to recognize NK receptor ligands. Thus, whereas ITK-dependent CD44(lo)CD122(lo) CD8(+) T cells appear to represent conventional CD8(+) T cells, IL-15-dependent CD44(hi)CD122(hi) CD8(+) T cells may have functions in both adaptive and innate immunity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-10704459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-10784451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-10952724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-10952725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-11015440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-11239443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-11602647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-11900992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-11994430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-12055226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-12070282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-12089507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-12150888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-12190927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-14500639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-15178577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-15357947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-15357948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-15528077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-15771581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-15932944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-16474399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-3100624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-3106474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-7687616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-8777721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-9620680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16880398-9846488
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12075-80
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16880398-Animals,
pubmed-meshheading:16880398-Antigens, CD44,
pubmed-meshheading:16880398-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16880398-Cell Proliferation,
pubmed-meshheading:16880398-Gene Deletion,
pubmed-meshheading:16880398-Interleukin-15,
pubmed-meshheading:16880398-Lymphocyte Subsets,
pubmed-meshheading:16880398-Mice,
pubmed-meshheading:16880398-Mice, Inbred C57BL,
pubmed-meshheading:16880398-Mice, Transgenic,
pubmed-meshheading:16880398-Phenotype,
pubmed-meshheading:16880398-Protein-Tyrosine Kinases,
pubmed-meshheading:16880398-Receptors, Interleukin-2,
pubmed-meshheading:16880398-Thymus Gland
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pubmed:year |
2006
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pubmed:articleTitle |
ITK and IL-15 support two distinct subsets of CD8+ T cells.
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pubmed:affiliation |
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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