Linked Life Data

16879951

Source:http://linkedlifedata.com/resource/pubmed/id/16879951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-9-11
pubmed:abstractText
Donor T cells present within hematopoietic stem cell transplants promote engraftment, contribute to T-cell reconstitution and provide an antileukemic effect. However, they are also responsible for the life-threatening graft-versus-host disease. The subpopulation of CD4+CD25hi regulatory T cells, initially identified as crucial players in the regulation of autoimmune processes, might also play a role in the control of alloreactivity. Experimental studies in mice indicate that donor regulatory T cells indeed control alloreactive responses and reduce graft-versus-host disease. Recent clinical reports also suggest that higher numbers of CD4+CD25hi cells within the transplant or in the blood of grafted patients might be associated with reduced graft-versus-host disease. Hence, these cells are attractive immunoregulatory candidates to prevent graft-versus-host disease in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0952-7915
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
580-5
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease.
pubmed:affiliation
CNRS, UMR7087, Université Pierre et Marie Curie, Hôpital Pitié Salpêtrière, 83, bd. de l'Hôpital, F-75651 Paris Cedex 13, France. jose.cohen@chups.jussieu.fr
pubmed:publicationType
Journal Article, Review