Linked Life Data

16878136

Source:http://linkedlifedata.com/resource/pubmed/id/16878136

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-8-22
pubmed:abstractText
T cells expressing an invariant V(alpha)19-J(alpha)33 T cell receptor alpha-chain (V(alpha)19i TCR) are restricted by the nonpolymorphic major histocompatibility complex class Ib molecule MR1. Whether V(alpha)19i T cells are involved in autoimmunity is not understood. Here we demonstrate that T cells expressing the V(alpha)19i TCR transgene inhibited the induction and progression of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Similarly, EAE was exacerbated in MR1-deficient mice, which lack V(alpha)19i T cells. EAE suppression was accompanied by reduced production of inflammatory mediators and increased secretion of interleukin 10. Interleukin 10 production occurred at least in part through interactions between B cells and V(alpha)19i T cells mediated by the ICOS costimulatory molecule. These results suggest an immunoregulatory function for V(alpha)19i T cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1529-2908
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
987-94
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16878136-Animals, pubmed-meshheading:16878136-Antigens, CD1, pubmed-meshheading:16878136-Antigens, CD1d, pubmed-meshheading:16878136-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:16878136-B-Lymphocytes, pubmed-meshheading:16878136-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:16878136-Histocompatibility Antigens Class I, pubmed-meshheading:16878136-Immunoglobulin Variable Region, pubmed-meshheading:16878136-Inducible T-Cell Co-Stimulator Protein, pubmed-meshheading:16878136-Interleukin-10, pubmed-meshheading:16878136-Lymphocyte Activation, pubmed-meshheading:16878136-Mice, pubmed-meshheading:16878136-Mice, Transgenic, pubmed-meshheading:16878136-Multiple Sclerosis, pubmed-meshheading:16878136-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:16878136-T-Lymphocytes, Regulatory
pubmed:year
2006
pubmed:articleTitle
Invariant V(alpha)19i T cells regulate autoimmune inflammation.
pubmed:affiliation
Department of Immunology, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Tokyo 187-8502, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't