| pubmed-article:16878028 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16878028 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:16878028 | lifeskim:mentions | umls-concept:C0036983 | lld:lifeskim |
| pubmed-article:16878028 | lifeskim:mentions | umls-concept:C1155266 | lld:lifeskim |
| pubmed-article:16878028 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16878028 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16878028 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16878028 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:16878028 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16878028 | pubmed:dateCreated | 2006-7-31 | lld:pubmed |
| pubmed-article:16878028 | pubmed:abstractText | Induction of the antiviral cytokine interferon alpha/beta (IFN-alpha/beta) is common in many viral infections. The impact of ongoing antiviral responses on subsequent bacterial infection is not well understood. In human disease, bacterial superinfection complicating a viral infection can result in significant morbidity and mortality. We injected mice with polyinosinic-polycytidylic (PIC) acid, a TLR3 ligand and known IFN-alpha/beta inducer as well as nuclear factor kappaB (NF-kappaB) activator to simulate very early antiviral pathways. We then challenged mice with an in vivo septic shock model characterized by slowly evolving bacterial infection to simulate bacterial superinfection early during a viral infection. Our data demonstrated robust induction of IFN-alpha in serum within 24 h of PIC injection with IFN-alpha/beta-dependent major histocompatibility antigen class II up-regulation on peritoneal macrophages. PIC pretreatment before septic shock resulted in augmented tumor necrosis factor alpha and interleukins 6 and 10 and heightened lethality compared with septic shock alone. Intact IFN-alpha/beta signaling was necessary for augmentation of the inflammatory response to in vivo septic shock and to both TLR2 and TLR4 agonists in vitro. To assess the NF-kappaB contribution to PIC-modulated inflammatory responses to septic shock, we treated with parthenolide, an NF-kappaB inhibitor before PIC and septic shock. Parthenolide did not inhibit IFN-alpha induction by PIC. Inhibition of NF-kappaB by parthenolide did reduce IFN-alpha-mediated potentiation of the cytokine response and lethality from septic shock. Our data demonstrate that pathways activated early during many viral infections can have a detrimental impact on the outcome of subsequent bacterial infection. These pathways may be critical to understanding the heightened morbidity and mortality from bacterial superinfection after viral infection in human disease. | lld:pubmed |
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| pubmed-article:16878028 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16878028 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16878028 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16878028 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16878028 | pubmed:issn | 1073-2322 | lld:pubmed |
| pubmed-article:16878028 | pubmed:author | pubmed-author:AyalaAlfredA | lld:pubmed |
| pubmed-article:16878028 | pubmed:author | pubmed-author:DoughtyLesley... | lld:pubmed |
| pubmed-article:16878028 | pubmed:author | pubmed-author:CarltonStacey... | lld:pubmed |
| pubmed-article:16878028 | pubmed:author | pubmed-author:GalenBenjamin... | lld:pubmed |
| pubmed-article:16878028 | pubmed:author | pubmed-author:Cooma-Rambera... | lld:pubmed |
| pubmed-article:16878028 | pubmed:author | pubmed-author:ChungChung-Sh... | lld:pubmed |
| pubmed-article:16878028 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16878028 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16878028 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16878028 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16878028 | pubmed:pagination | 187-94 | lld:pubmed |
| pubmed-article:16878028 | pubmed:dateRevised | 2010-9-17 | lld:pubmed |
| pubmed-article:16878028 | pubmed:meshHeading | pubmed-meshheading:16878028... | lld:pubmed |
| pubmed-article:16878028 | pubmed:meshHeading | pubmed-meshheading:16878028... | lld:pubmed |
| pubmed-article:16878028 | pubmed:meshHeading | pubmed-meshheading:16878028... | lld:pubmed |
| pubmed-article:16878028 | pubmed:meshHeading | pubmed-meshheading:16878028... | lld:pubmed |
