Linked Life Data

16876888

Source:http://linkedlifedata.com/resource/pubmed/id/16876888

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-8-21
pubmed:abstractText
Previous findings indicated that intra-cerebral as well as systemic injections of glucocorticoid hormones shortly before retention testing induce impairment of long-term memory retrieval, but the underlying mechanisms (genomic or non-genomic) are not known. To clarify this issue, we investigated the involvement of protein synthesis in the hippocampus in glucocorticoid-induced impairment of memory retrieval. Young rats carrying bilateral cannulae aimed at the hippocampus were trained in a water maze (MWM) task with six trials per day for six consecutive days. Retention of the spatial training was assessed 24h after the last training session with a 60-s probe trial. Corticosterone (1mg/kg) was injected 30 min before retention testing with or without prior bilateral intra-hippocampal injections of anisomycin (80 or 160 microg/mul per site) as an inhibitor of protein synthesis. The control animals received vehicle or saline solutions. The results show that corticosterone-induced impairment of memory retrieval was not blocked by intra-hippocampal infusions of anisomycin. Our data suggest that corticosterone influences memory retrieval via a protein independent mechanism and provide evidence for rapid actions (non-genomic) of glucocorticoids on memory retrieval.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
173
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Intra-hippocampal microinjections of anisomycin did not block glucocorticoid-induced impairment of memory retrieval in rats: an evidence for non-genomic effects of glucocorticoids.
pubmed:affiliation
Laboratory of Learning and Memory, Physiological Research Center, Semnan University of Medical Sciences, P.O. Box 35195-163, Semnan, Iran.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't