Linked Life Data

16876224

Source:http://linkedlifedata.com/resource/pubmed/id/16876224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-10-2
pubmed:abstractText
Six morphine-exposed and 3 control male Indian rhesus macaques were intravenously inoculated with mixture of SHIV(KU), SHIV(89.6)P and SIV/17E-Fr. These animals were followed for a period of 56 weeks in order to determine CD4 and CD8 profile, viral loads in plasma and cerebrospinal fluid (CSF), relative distribution of 3 pathogenic viruses in blood and brain, binding as well neutralizing antibody levels and cellular immune responses. Both morphine-exposed and control macaques showed a precipitous loss of CD4+ T cells; control animals, however, showed a greater tendency to recover these cells than did their morphine-exposed counterparts. The plasma and CSF viral loads were significantly higher in morphine-exposed group than those in the control group. Four morphine-exposed animals succumbed to SIV/SHIV-induced AIDS at week 18, 19, 20 and 51; post-infection with neurological disorders was found in 3 of the 4 animals. At the end of the 56-week observation period, 2 morphine-exposed and 3 control animals were still alive. All 3 viruses replicated in the blood of both morphine-exposed and control macaques, but the cerebral compartment showed a selection phenomenon; only SIV/17E-Fr and SHIV(KU) successfully crossed the blood brain barrier (BBB). The morphine-exposed macaques further favored viral migration through the blood brain barrier (BBB). SIV/17E-Fr crossed the BBB within 2 weeks in both morphine-exposed and control macaques, whereas SHIV(KU) crossed the BBB more rapidly in morphine-exposed than in control macaques. Three morphine-exposed macaques (euthanized at weeks 18, 19 and 20) did not develop cellular or humoral immune responses, whereas the other 3 morphine-exposed and 3 control macaques developed both cellular and humoral immune responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
354
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
192-206
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16876224-Acquired Immunodeficiency Syndrome, pubmed-meshheading:16876224-Animals, pubmed-meshheading:16876224-Antibodies, Viral, pubmed-meshheading:16876224-CD4 Lymphocyte Count, pubmed-meshheading:16876224-CD4-CD8 Ratio, pubmed-meshheading:16876224-Cerebrospinal Fluid, pubmed-meshheading:16876224-Disease Models, Animal, pubmed-meshheading:16876224-Immunity, Cellular, pubmed-meshheading:16876224-Macaca mulatta, pubmed-meshheading:16876224-Male, pubmed-meshheading:16876224-Morphine, pubmed-meshheading:16876224-RNA, Viral, pubmed-meshheading:16876224-Simian Acquired Immunodeficiency Syndrome, pubmed-meshheading:16876224-Simian immunodeficiency virus, pubmed-meshheading:16876224-Telencephalon, pubmed-meshheading:16876224-Viral Load, pubmed-meshheading:16876224-Virus Replication
pubmed:year
2006
pubmed:articleTitle
Chronic morphine exposure causes pronounced virus replication in cerebral compartment and accelerated onset of AIDS in SIV/SHIV-infected Indian rhesus macaques.
pubmed:affiliation
Laboratory of Viral Immunology, AIDS Research Program and Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural