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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1992-6-18
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pubmed:abstractText |
To study the effect of ambroxol on ion transport functions of airway mucosa, we measured bioelectric properties of canine cultured tracheal epithelium under short-circuit conditions in-vitro. Addition of ambroxol to the submucosal but not to the mucosal solution in an Ussing chamber decreased short-circuit current, transepithelial potential difference and cell conductance. The ambroxol-induced decrease in short-circuit current was not affected by bumetanide or diphenylamine-2-carboxylate, but it was abolished by pretreatment of cells with amiloride. These results suggest that ambroxol may selectively inhibit Na+ absorption by airway epithelium, thereby increasing water composition in airway surface fluid and reducing mucus viscosity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3573
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
841-3
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1687582-Absorption,
pubmed-meshheading:1687582-Ambroxol,
pubmed-meshheading:1687582-Amiloride,
pubmed-meshheading:1687582-Animals,
pubmed-meshheading:1687582-Anthranilic Acids,
pubmed-meshheading:1687582-Body Water,
pubmed-meshheading:1687582-Bumetanide,
pubmed-meshheading:1687582-Cells, Cultured,
pubmed-meshheading:1687582-Depression, Chemical,
pubmed-meshheading:1687582-Dogs,
pubmed-meshheading:1687582-Electrophysiology,
pubmed-meshheading:1687582-Epithelium,
pubmed-meshheading:1687582-Female,
pubmed-meshheading:1687582-Male,
pubmed-meshheading:1687582-Mucous Membrane,
pubmed-meshheading:1687582-Respiratory System,
pubmed-meshheading:1687582-Sodium,
pubmed-meshheading:1687582-Trachea,
pubmed-meshheading:1687582-Viscosity
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pubmed:year |
1991
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pubmed:articleTitle |
Ambroxol inhibits Na+ absorption by canine airway epithelial cells in culture.
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pubmed:affiliation |
First Department of Medicine, Tokyo Women's Medical College, Japan.
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pubmed:publicationType |
Journal Article
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