Source:http://linkedlifedata.com/resource/pubmed/id/16873762
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2006-10-30
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| pubmed:abstractText |
Previous studies have shown the relevance of bone marrow-derived MSCs (BM-MSCs) in controlling graft-versus-host disease (GVHD) after allogeneic transplantation. Since adipose tissue-derived MSCs (Ad-MSCs) may constitute a good alternative to BM-MSCs, we have expanded MSCs derived from human adipose tissue (hAd-MSCs) and mouse adipose tissue (mAd-MSCs), investigated the immunoregulatory properties of these cells, and evaluated their capacity to control GVHD in mice. The phenotype and immunoregulatory properties of expanded hAd-MSCs were similar to those of human BM-MSCs. Moreover, hAd-MSCs inhibited the proliferation and cytokine secretion of human primary T cells in response to mitogens and allogeneic T cells. Similarly, ex vivo expanded mAd-MSCs had an equivalent immunophenotype and exerted immunoregulatory properties similar to those of hAd-MSCs. Moreover, the infusion of mAd-MSCs in mice transplanted with haploidentical hematopoietic grafts controlled the lethal GVHD that occurred in control recipient mice. These findings constitute the first experimental proof that Ad-MSCs can efficiently control the GVHD associated with allogeneic hematopoietic transplantation, opening new perspectives for the clinical use of Ad-MSCs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1066-5099
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2582-91
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| pubmed:meshHeading |
pubmed-meshheading:16873762-Adipose Tissue,
pubmed-meshheading:16873762-Animals,
pubmed-meshheading:16873762-Bone Marrow Cells,
pubmed-meshheading:16873762-Cell Communication,
pubmed-meshheading:16873762-Cells, Cultured,
pubmed-meshheading:16873762-Coculture Techniques,
pubmed-meshheading:16873762-Cytokines,
pubmed-meshheading:16873762-Flow Cytometry,
pubmed-meshheading:16873762-Graft vs Host Disease,
pubmed-meshheading:16873762-Humans,
pubmed-meshheading:16873762-Immunophenotyping,
pubmed-meshheading:16873762-Lymphocyte Activation,
pubmed-meshheading:16873762-Mesenchymal Stem Cell Transplantation,
pubmed-meshheading:16873762-Mesenchymal Stem Cells,
pubmed-meshheading:16873762-Mice,
pubmed-meshheading:16873762-Mitogens,
pubmed-meshheading:16873762-Phytohemagglutinins,
pubmed-meshheading:16873762-T-Lymphocytes
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease.
|
| pubmed:affiliation |
Hematopoiesis and Gene Therapy Division, Centro de Investigaciones Energéticas, Medioambientales y Technologicas (CIEMAT)/Marcelino Botín Foundation, Madrid, Spain.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|