Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-5-26
pubmed:abstractText
Taxol, an antineoplastic agent isolated from the Pacific yew, has been demonstrated in three phase 2 clinical trials to have major activity (30 percent overall response rate) in patients with ovarian cancer refractory to cisplatin. The major toxicities associated with the agent are neutropenia (dose-limiting), hypersensitivity reactions, peripheral sensory neuropathy, and cardiac arrhythmias. A recently reported phase 1 trial of the combination of cisplatin and taxol has defined acceptable doses for the two-drug combination to be tested against cisplatin and cyclophosphamide as frontline therapy of advanced ovarian cancer. Taxol has also been examined for intraperitoneal administration in patients with ovarian cancer, with a major pharmacokinetic advantage for peritoneal cavity exposure being demonstrated. Unfortunately, any future development of taxol as an antineoplastic agent in the management of ovarian cancer will be dependent on the finding of an alternative source of the drug, as the current method of obtaining taxol from the bark of the Pacific yew provides insufficient quantities for large-scale clinical use.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-1970948, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-1972736, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-1973737, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-1999708, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2404837, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2568175, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2569287, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2688324, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2871137, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2871928, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2872974, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2882837, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2887641, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2890527, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2891441, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2891442, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2898289, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2898915, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-2926470, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-3091778, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-3095501, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-3102056, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-3114434, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-3124679, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-3556023, http://linkedlifedata.com/resource/pubmed/commentcorrection/1687343-5553076
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-0086
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
583-90
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:articleTitle
Taxol: an important new drug in the management of epithelial ovarian cancer.
pubmed:affiliation
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
pubmed:publicationType
Journal Article, Review