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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2006-8-14
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pubmed:abstractText |
Novel diazirine or biotin-labeled tanshinone probes were synthesized and evaluated for TRAP inhibitory activity against RANKL-induced osteoclastogenesis in RAW264.7 cells. We found that diazirine-labeled derivatives (18 and 20) are potent inhibitors of RANKL-induced osteoclastogenesis. IC50 values were 18.02 and 15.00 microM, respectively. These probes will be useful reagents for investigating tanshinone-proteins interactions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes, Abietane,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/tanshinone,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4733-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16872829-Acid Phosphatase,
pubmed-meshheading:16872829-Animals,
pubmed-meshheading:16872829-Carrier Proteins,
pubmed-meshheading:16872829-Cell Line,
pubmed-meshheading:16872829-Cell Proliferation,
pubmed-meshheading:16872829-Diterpenes, Abietane,
pubmed-meshheading:16872829-Hydrogen,
pubmed-meshheading:16872829-Isoenzymes,
pubmed-meshheading:16872829-Membrane Glycoproteins,
pubmed-meshheading:16872829-Mice,
pubmed-meshheading:16872829-Molecular Structure,
pubmed-meshheading:16872829-Osteoclasts,
pubmed-meshheading:16872829-Osteogenesis,
pubmed-meshheading:16872829-Phenanthrenes,
pubmed-meshheading:16872829-Proteins,
pubmed-meshheading:16872829-RANK Ligand,
pubmed-meshheading:16872829-Receptor Activator of Nuclear Factor-kappa B
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pubmed:year |
2006
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pubmed:articleTitle |
Synthesis of novel chemical probes for the study of tanshinone binding proteins.
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pubmed:affiliation |
Laboratory of Chemical Genomics, Bio-Organic Science Division, Korea Research Institute of Chemical Technology, Deajeon 305-600, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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