Linked Life Data

16872764

Source:http://linkedlifedata.com/resource/pubmed/id/16872764

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2006-10-23
pubmed:abstractText
Spironolactone is a steroidal diuretic showing incomplete oral behaviour because of its low solubility and slow dissolution rate. In this study, we applied the nanoprecipitation method to prepare spironolactone-loaded nanocapsules, at laboratory-scale and pilot-scale. The effect of several formulation variables on the spironolactone-loaded nanocapsules properties (average size, drug release rate and drug entrapment) was investigated. The optimized formulations at laboratory-scale and pilot-scale lead to the preparation of spironolactone-loaded nanocapsules with a mean size of 320 and 400 nm, respectively, a high encapsulation efficiency (96.21% and 90.56% respectively), both stable for 6 months. The release of spironolactone from nanocapsules was rapid and complete in a simulated gastric fluid, therefore recourse to spironolactone nanoencapsulation should enhance its oral bioavailability and probably its efficiency. The optimized formulations lead to a high drug-concentration in the liquid preparation (1.5 mg/ml) allowing minimizing the preparation volume administered for children medication.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0378-5173
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
325
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-31
pubmed:dateRevised
2008-8-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Preparation and characterization of spironolactone-loaded nanocapsules for paediatric use.
pubmed:affiliation
Laboratoire d'Automatique et de Génie des Procédés (LAGEP), UMR-CNRS 5007, CPE Lyon, Université Claude Bernard Lyon 1, Bât 308 G, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France. limayem@lagep.univ-lyon.fr
pubmed:publicationType
Journal Article