Linked Life Data

1687222

Source:http://linkedlifedata.com/resource/pubmed/id/1687222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1992-5-14
pubmed:abstractText
The human uterine artery was studied by immunocytochemistry and in vitro pharmacology. Nerve fibres containing immunoreactivity for neuropeptide Y (NPY) were encountered in the media, adventitia, smooth muscle layers and surrounding the vasa vasorum. Approximately 50% of the nerve fibres containing NPY also stored immunoreactivity for tyrosine hydroxylase (TH) and TH activity was found in no other fibres. Noradrenaline (NA) contracted the isolated uterine artery in a concentration dependent manner. The presence of increasing doses of NPY shifted the concentration-response curve for NA to the left. Consequently the pD2-values were increased indicating a potentiation of the adrenergic effects induced by NPY. The results demonstrate the existence of NPY in adrenergic nerve fibres surrounding the human uterine artery. A close co-operation between NPY and NA in the neuronal control of smooth muscle is suggested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0268-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1034-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Neuropeptide Y (NPY) co-exists with tyrosine hydroxylase and potentiates the adrenergic contractile response of vascular smooth muscle in the human uterine artery.
pubmed:affiliation
Department of Obstetrics and Gynaecology, University of Lund, Malmö, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't