Linked Life Data

16872136

Source:http://linkedlifedata.com/resource/pubmed/id/16872136

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-7-28
pubmed:abstractText
Maytenus ilicifolia is a medicinal plant used as a tea (infusion) for treatment of stomach ulcers. This tea furnished a polysaccharide after several purification steps, consisting of a freezing-thawing process, Fehling precipitation, ultrafiltration, and dialysis. It consisted of arabinose, galactose, galacturonic acid, 4-O-methylglucuronic acid, rhamnose, and glucose in a 42:41:6:5:4:2 molar ratio. Methylation analysis, controlled Smith degradation, and NMR spectroscopy indicated that it was a type II arabinogalactan containing a (1-->3)-linked beta-d-Galp main chain, substituted at O-6 by (1-->6)-linked beta-d-Galp chains, which were mainly substituted at O-3 by (1-->5)- and (1-->3)-linked alpha-l-Araf chains, and nonreducing end-units of alpha-l-Araf and 4-O-Me-GlcpA. This polysaccharide significantly inhibited ethanol-induced gastric lesions in rats with an ED(50) of 9.3 mg/kg, suggesting that the arabinogalactan liberated from the infusion has a protective anti-ulcer effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1018-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
A polysaccharide from a tea (infusion) of Maytenus ilicifolia leaves with anti-ulcer protective effects.
pubmed:affiliation
Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP-19046, CEP-81531-990, Curitiba, PR, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't