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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-5-4
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pubmed:abstractText |
The role played by dopamine D1 and D2 receptors in formalin test analgesia was explored by challenging D-amphetamine- and morphine-induced analgesia with mixed and selective D1 and D2 antagonists, and by examining the relative analgesic activity of mixed and selective D1 and D2 agonists. The mixed D1/D2 dopamine antagonist cis-flupenthixol (0.5 mg/kg), the D2 antagonist pimozide (0.5 mg/kg), and the D1 antagonist SCH 23390 (0.1 mg/kg) attenuated both D-amphetamine and morphine analgesia. The mixed D1/D2 agonist apomorphine and the selective D2 agonist quinpirole produced dose-dependent analgesia while the selective D1 agonist SKF 38393 was without effect. These data suggest that D1 receptors play an "enabling" role in D2 receptor-mediated analgesia in the formalin test.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-p...,
http://linkedlifedata.com/resource/pubmed/chemical/Apomorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Dextroamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ergolines,
http://linkedlifedata.com/resource/pubmed/chemical/Flupenthixol,
http://linkedlifedata.com/resource/pubmed/chemical/Formaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Pimozide,
http://linkedlifedata.com/resource/pubmed/chemical/Quinpirole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0091-3057
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-22
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1687167-2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine,
pubmed-meshheading:1687167-Analgesia,
pubmed-meshheading:1687167-Animals,
pubmed-meshheading:1687167-Apomorphine,
pubmed-meshheading:1687167-Benzazepines,
pubmed-meshheading:1687167-Dextroamphetamine,
pubmed-meshheading:1687167-Dopamine Agents,
pubmed-meshheading:1687167-Dopamine Antagonists,
pubmed-meshheading:1687167-Dose-Response Relationship, Drug,
pubmed-meshheading:1687167-Ergolines,
pubmed-meshheading:1687167-Flupenthixol,
pubmed-meshheading:1687167-Formaldehyde,
pubmed-meshheading:1687167-Male,
pubmed-meshheading:1687167-Morphine,
pubmed-meshheading:1687167-Pain,
pubmed-meshheading:1687167-Pimozide,
pubmed-meshheading:1687167-Quinpirole,
pubmed-meshheading:1687167-Rats,
pubmed-meshheading:1687167-Receptors, Dopamine,
pubmed-meshheading:1687167-Receptors, Dopamine D1,
pubmed-meshheading:1687167-Receptors, Dopamine D2
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pubmed:year |
1991
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pubmed:articleTitle |
Dopamine receptor subtypes and formalin test analgesia.
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pubmed:affiliation |
Department of Psychology, McGill University, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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