Source:http://linkedlifedata.com/resource/pubmed/id/16871568
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-8-2
|
| pubmed:abstractText |
The outcome of acute hepatitis B virus (HBV) infection is variable, influenced by host and viral factors. From 1982 through 2004, 301 patients with acute HBV infection entered a multi-center cross-sectional study in Japan. Patients with fulminant hepatitis (n = 40) were older (44.7 +/- 16.3 vs. 36.0 +/- 14.3 years, P < .0017), less predominantly male (43% vs. 71%, P = .0005), less positive for hepatitis B e antigen (HBeAg) (23% vs. 60%, P < .0001), less infected with subgenotype Ae (0% vs. 13%, P < .05), and more frequently with Bj (30% vs. 4%, P < .0001) than those with acute self-limited hepatitis (n = 261). Precore (G1896A) and core-promoter (A1762T/G1764A) mutations were more frequent in patients with fulminant than acute self-limited hepatitis (53% vs. 9% and 50% vs. 17%, P < .0001 for both). HBV infection persisted in only three (1%) patients, and they represented 2 of the 23 infected with Ae and 1 of the 187 with the other subgenotypes (9% vs. 0.5%, P = .032); none of them received antiviral therapy. In multivariate analysis, age 34 years or older, Bj, HBeAg-negative, total bilirubin 10.0 mg/dL or greater, and G1896A mutation were independently associated with the fulminant outcome. In in vitro transfection experiments, the replication of Bj clone was markedly enhanced by introducing either G1896A or A1762T/G1764A mutation. In conclusion, persistence of HBV was rare (1%) and associated with Ae, whereas fulminant hepatitis was frequent (13%) and associated with Bj and lack of HBeAg as well as high replication due to precore mutation in patients with acute HBV infection.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0270-9139
|
| pubmed:author |
pubmed-author:AsahinaYasuhiroY,
pubmed-author:HigeShuheiS,
pubmed-author:HinoKeisukeK,
pubmed-author:InoueKazuakiK,
pubmed-author:KakumuShinichiS,
pubmed-author:KangJong-HonJH,
pubmed-author:KuramitsuTomoyukiT,
pubmed-author:MiyakawaYuzoY,
pubmed-author:MizokamiMasashiM,
pubmed-author:MurawakiYoshikazuY,
pubmed-author:OkadaShunichiS,
pubmed-author:OkanoueTakeshiT,
pubmed-author:OnjiMorikazuM,
pubmed-author:OritoEtsuroE,
pubmed-author:OzasaAtsushiA,
pubmed-author:SakugawaHiroshiH,
pubmed-author:SugiyamaMasayaM,
pubmed-author:SuzukiKazuyukiK,
pubmed-author:TanakaEijiE,
pubmed-author:TanakaYasuhitoY,
pubmed-author:TokitaHajimeH,
pubmed-author:UedaRyuzoR,
pubmed-author:YatsuhashiHiroshiH
|
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
326-34
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16871568-Acute Disease,
pubmed-meshheading:16871568-Adult,
pubmed-meshheading:16871568-Chronic Disease,
pubmed-meshheading:16871568-Cross-Sectional Studies,
pubmed-meshheading:16871568-DNA, Viral,
pubmed-meshheading:16871568-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16871568-Female,
pubmed-meshheading:16871568-Follow-Up Studies,
pubmed-meshheading:16871568-Genotype,
pubmed-meshheading:16871568-Hepatitis B,
pubmed-meshheading:16871568-Hepatitis B e Antigens,
pubmed-meshheading:16871568-Hepatitis B virus,
pubmed-meshheading:16871568-Humans,
pubmed-meshheading:16871568-Incidence,
pubmed-meshheading:16871568-Japan,
pubmed-meshheading:16871568-Male,
pubmed-meshheading:16871568-Mutation,
pubmed-meshheading:16871568-Polymerase Chain Reaction,
pubmed-meshheading:16871568-Prognosis,
pubmed-meshheading:16871568-Radioimmunoassay,
pubmed-meshheading:16871568-Retrospective Studies,
pubmed-meshheading:16871568-Viral Core Proteins,
pubmed-meshheading:16871568-Virus Replication
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection.
|
| pubmed:affiliation |
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
|