Source:http://linkedlifedata.com/resource/pubmed/id/16870003
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-7-27
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| pubmed:abstractText |
Diet-induced changes in the activities of bacterial enzymes are known to play a role in colon cancer development. Resveratrol has been implicated as a protective agent in carcinogenesis. In the present study, the effect of resveratrol on the activities of faecal and colonic biotransforming enzymes such as beta-glucuronidase, beta-glucosidase, beta-galactosidase, mucinase, nitroreductase and faecal sulfatase activity was assessed. The total number of aberrant crypt foci and their distribution in the proximal, medial and distal colon were observed in 1,2-dimethylhydrazine (DMH)-induced rats (group 3) and other treatment groups (groups 4-6). DMH (0.02 g/kg body weight) was given subcutaneously once a week for 15 consecutive weeks, and the experiment was terminated at 30 weeks. DMH-treated rats showed elevated levels of cancer-associated bacterial enzyme activities, whereas on resveratrol supplementation in three different regimens, rats showed lowered activities. Resveratrol supplementation throughout the experimental period (group 6) exerted a more pronounced effect (P < 0.01) by modulating the development of aberrant crypt foci and the activities of bacterial enzymes than did the other treatment regimens (groups 4 and 5). Thus, the present results demonstrate the inhibitory effect of resveratrol on DMH-induced colon carcinogenesis in rats.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-Dimethylhydrazine,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoside Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharide-Lyases,
http://linkedlifedata.com/resource/pubmed/chemical/Stilbenes,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfatases,
http://linkedlifedata.com/resource/pubmed/chemical/hyaluronate lyase,
http://linkedlifedata.com/resource/pubmed/chemical/resveratrol
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
0007-1145
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
96
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
145-53
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16870003-1,2-Dimethylhydrazine,
pubmed-meshheading:16870003-Animals,
pubmed-meshheading:16870003-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:16870003-Bacteria,
pubmed-meshheading:16870003-Carcinogens,
pubmed-meshheading:16870003-Colon,
pubmed-meshheading:16870003-Colonic Neoplasms,
pubmed-meshheading:16870003-Dietary Supplements,
pubmed-meshheading:16870003-Disease Models, Animal,
pubmed-meshheading:16870003-Feces,
pubmed-meshheading:16870003-Glycoside Hydrolases,
pubmed-meshheading:16870003-Intestinal Mucosa,
pubmed-meshheading:16870003-Male,
pubmed-meshheading:16870003-Nitroreductases,
pubmed-meshheading:16870003-Polysaccharide-Lyases,
pubmed-meshheading:16870003-Precancerous Conditions,
pubmed-meshheading:16870003-Rats,
pubmed-meshheading:16870003-Rats, Wistar,
pubmed-meshheading:16870003-Stilbenes,
pubmed-meshheading:16870003-Sulfatases
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| pubmed:year |
2006
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| pubmed:articleTitle |
Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development.
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| pubmed:affiliation |
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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