Source:http://linkedlifedata.com/resource/pubmed/id/16868891
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2006-7-26
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pubmed:abstractText |
Although hypopituitarism is a known complication of traumatic head injury, it may be under-recognized due to its subtle clinical manifestations. To address this issue, we determine the prevalence of neuroendocrine abnormalities in patients rehabilitating from severe traumatic brain injury (Glasgow Coma Scale < or = 8). 76 patients (mean age 39 +/- 14 yr; range 18-65; 53 males and 23 females; BMI 25.8 +/- 4.2 kg/m2; mean +/- SD) with a severe traumatic brain injury, an average of 22 +/- 10 months before this study (median, 20 months), underwent a series of standard endocrine tests, including TSH, free T4, T4, T3, prolactin, testosterone (males), estradiol (females), cortisol, ACTH, GH, and IGF-I. All subjects also underwent GH response to GHRH + arginine. Growth hormone deficiency (GHD) was defined as a GH response < 9 microg/L to GHRH + arginine and was confirmed by ITT (< 3 microg/L). Pituitary deficiency was shown in 24% of the patients (18/76). 8% (n = 6) had GHD (GH-peak range [GHRH + arginine]: 2.8-6.3 microg/L; GH-peak range [ITT]: 1.5-2.2 microg/L; IGF-I range: 62-174 microg/L). 17% (n = 13) had hypogonadism (total testosterone < 9.5 nmol/L and low gonadotropins in 12 males; low estradiol, and low gonadotropins in 1 female). Total testosterone levels did not correlate with BMI or age. 2 males with hypogonadism also showed a mild hyperprolactinemia (33 and 41 ng/ml). 3% (n = 2) patients had partial ACTH-deficiency (cortisol-peak [ITT] 392 and 417 nmol/L) and 3% (n = 2) had TSH-deficiency. In summary, we have found hypopituitarism in one-fourth of patients with predominantly secondary hypogonadism and GHD. These findings strongly suggest that patients who suffer head trauma must routinely include neuroendocrine evaluations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0947-7349
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
316-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16868891-Adolescent,
pubmed-meshheading:16868891-Adrenocorticotropic Hormone,
pubmed-meshheading:16868891-Adult,
pubmed-meshheading:16868891-Aged,
pubmed-meshheading:16868891-Brain Injuries,
pubmed-meshheading:16868891-Female,
pubmed-meshheading:16868891-Growth Hormone,
pubmed-meshheading:16868891-Humans,
pubmed-meshheading:16868891-Hypogonadism,
pubmed-meshheading:16868891-Hypopituitarism,
pubmed-meshheading:16868891-Male,
pubmed-meshheading:16868891-Middle Aged,
pubmed-meshheading:16868891-Prevalence,
pubmed-meshheading:16868891-Prospective Studies,
pubmed-meshheading:16868891-Thyrotropin
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pubmed:year |
2006
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pubmed:articleTitle |
Hypopituitarism following severe traumatic brain injury.
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pubmed:affiliation |
Institute of Cardio-Diabetes, Technology-Center Bochum, Bochum, Germany. burkhard.herrmann@uni-essen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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