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pubmed-article:16867708rdf:typepubmed:Citationlld:pubmed
pubmed-article:16867708lifeskim:mentionsumls-concept:C0036773lld:lifeskim
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pubmed-article:16867708pubmed:issue1lld:pubmed
pubmed-article:16867708pubmed:dateCreated2006-7-26lld:pubmed
pubmed-article:16867708pubmed:abstractTextThe binding of the anti-inflammatory drug, flurbiprofen, to human serum albumin is accompanied by a reduction of the fluorescence efficiency of the drug. The quenching effect has been used to evaluate the strength of binding at different pH values. Equations have also been developed for calculating binding constants for a 1:1 drug-protein complex, when fluorescence measurements are made at wavelengths where the emission spectra of the free drug, free protein and the complex overlap. Over the pH range 6.20-8.04, a binding constant of ca 1.0 x 10(7) was found for flurbiprofen.lld:pubmed
pubmed-article:16867708pubmed:languageenglld:pubmed
pubmed-article:16867708pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16867708pubmed:statusPubMed-not-MEDLINElld:pubmed
pubmed-article:16867708pubmed:issn0731-7085lld:pubmed
pubmed-article:16867708pubmed:authorpubmed-author:SchulmanS GSGlld:pubmed
pubmed-article:16867708pubmed:authorpubmed-author:PerrinJ HJHlld:pubmed
pubmed-article:16867708pubmed:authorpubmed-author:TaklaP GPGlld:pubmed
pubmed-article:16867708pubmed:issnTypePrintlld:pubmed
pubmed-article:16867708pubmed:volume3lld:pubmed
pubmed-article:16867708pubmed:ownerNLMlld:pubmed
pubmed-article:16867708pubmed:authorsCompleteYlld:pubmed
pubmed-article:16867708pubmed:pagination41-50lld:pubmed
pubmed-article:16867708pubmed:year1985lld:pubmed
pubmed-article:16867708pubmed:articleTitleMeasurement of flurbiprofen-human serum albumin interaction by fluorimetry.lld:pubmed
pubmed-article:16867708pubmed:affiliationCollege of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA.lld:pubmed
pubmed-article:16867708pubmed:publicationTypeJournal Articlelld:pubmed
literatureCitation:587_1686...literatureCitation:pubmedpubmed-article:16867708lld:drugbank