Source:http://linkedlifedata.com/resource/pubmed/id/16867157
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-7-26
|
| pubmed:abstractText |
To probe the potential role of Th1 versus Th2 reactivity underlying the hygiene hypothesis, intrinsic levels of Th1-associated and Th2-associated antibodies in the serum of wild rodents were compared with that in various strains of laboratory rodents. Studies using rat lung antigens as a target indicated that wild rats have substantially greater levels of autoreactive, polyreactive immunoglobulin G (IgG), but not autoreactive, polyreactive IgM than do laboratory rats, both on a quantitative and qualitative basis. Increased levels of serum IgG and IgE were observed in both wild rats and wild mice relative to their laboratory-raised counterparts, with the effect being most pronounced for IgE levels. Further, wild rats had greater intrinsic levels of both Th1- and Th2-associated IgG subclasses than did lab rats. The habitat (wild versus laboratory raised) had a more substantial impact on immunoglobulin concentration than did age, strain or gender in the animals studied. The presence in wild rodents of increased intrinsic, presumably protective, non-pathogenic responses similar to both autoimmune (autoreactive IgG, Th1-associated) and allergic (IgE, Th2-associated) reactions as well as increased levels of Th1-associated and Th2-associated IgG subclasses points toward a generally increased stimulation of the immune system in these animals rather than a shift in the nature of the immunoreactivity. It is concluded that, at least to the extent that feedback inhibition is a controlling element of immunoreactivity, an overly hygienic environment may affect the threshold of both types of immune responses more so than the balance between the different responses.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
0300-9475
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
64
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
125-36
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:16867157-Animals,
pubmed-meshheading:16867157-Animals, Laboratory,
pubmed-meshheading:16867157-Animals, Wild,
pubmed-meshheading:16867157-Antibody Formation,
pubmed-meshheading:16867157-Autoimmunity,
pubmed-meshheading:16867157-Environment,
pubmed-meshheading:16867157-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16867157-Female,
pubmed-meshheading:16867157-Hygiene,
pubmed-meshheading:16867157-Hypersensitivity,
pubmed-meshheading:16867157-Immunoglobulin E,
pubmed-meshheading:16867157-Immunoglobulin G,
pubmed-meshheading:16867157-Immunoglobulin M,
pubmed-meshheading:16867157-Male,
pubmed-meshheading:16867157-Mice,
pubmed-meshheading:16867157-Mice, Inbred Strains,
pubmed-meshheading:16867157-Rats,
pubmed-meshheading:16867157-Rodentia,
pubmed-meshheading:16867157-Th1 Cells,
pubmed-meshheading:16867157-Th2 Cells
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Increased levels of IgE and autoreactive, polyreactive IgG in wild rodents: implications for the hygiene hypothesis.
|
| pubmed:affiliation |
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|