16866884

Source:http://linkedlifedata.com/resource/pubmed/id/16866884

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011854, umls-concept:C0021920, umls-concept:C0332281, umls-concept:C0332307, umls-concept:C1413226, umls-concept:C1707076, umls-concept:C1882417
pubmed:issue	2
pubmed:dateCreated	2006-7-26
pubmed:abstractText	Type 1 diabetes is an autoimmune heterogeneous disease that is determined by environmental and genetic factors. A possible retroviral etiology has been inferred from the observation that human endogenous retrovirus (HERV)-K18 encoding a superantigen (SAg) has a polymorphism associated with this disease. Type 1 diabetes families from Germany and Belgium were genotyped for the novel HERV-8914 (303 families) and for the known HERV-8594 (284 families) polymorphisms within the SAg-coding region on the HERV-K18. Case-control analysis was performed for the HERV-8914 polymorphism (506 patients) and for the HERV-8594 polymorphism (370 patients) and compared with 350 German controls. Haplotypes were constructed. Additionally, a microsatellite within the CD48 gene was analyzed in German type 1 diabetes families (n=125) as well as in patients (n=375) and in healthy controls (n=350). No association was found for HERV-K18 polymorphisms or the CA repeat within the CD48 gene with type 1 diabetes mellitus either in families or by comparing patients and controls. In conclusion, we cannot confirm a role of HERV-K18 polymorphisms -HERV-8914 and HERV-8594- or of the CD48 CA repeat for type 1 diabetes susceptibility.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0331072
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/CD48 antigen, http://linkedlifedata.com/resource/pubmed/chemical/IDDMK1,2 22 superantigen, human, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Superantigens
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0001-2815
pubmed:author	pubmed-author:AminkengFF, pubmed-author:BadenhoopKK, pubmed-author:GhebruSS, pubmed-author:HerwigJJ, pubmed-author:Ramos-LopezEE, pubmed-author:SeidaHH, pubmed-author:SeifriedEE, pubmed-author:Van AutreveJJ, pubmed-author:Van der AuweraBB
pubmed:issnType	Print
pubmed:volume	68
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	147-52
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16866884-Antigens, CD, pubmed-meshheading:16866884-Case-Control Studies, pubmed-meshheading:16866884-Child, pubmed-meshheading:16866884-Child, Preschool, pubmed-meshheading:16866884-Diabetes Mellitus, Type 1, pubmed-meshheading:16866884-Dinucleotide Repeats, pubmed-meshheading:16866884-Endogenous Retroviruses, pubmed-meshheading:16866884-Female, pubmed-meshheading:16866884-Genetic Predisposition to Disease, pubmed-meshheading:16866884-Genotype, pubmed-meshheading:16866884-Humans, pubmed-meshheading:16866884-Introns, pubmed-meshheading:16866884-Linkage Disequilibrium, pubmed-meshheading:16866884-Male, pubmed-meshheading:16866884-Membrane Proteins, pubmed-meshheading:16866884-Polymorphism, Genetic, pubmed-meshheading:16866884-Software, pubmed-meshheading:16866884-Superantigens
pubmed:year	2006
pubmed:articleTitle	Neither an intronic CA repeat within the CD48 gene nor the HERV-K18 polymorphisms are associated with type 1 diabetes.
pubmed:affiliation	Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt am Main, Germany.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't