Linked Life Data

16866307

Source:http://linkedlifedata.com/resource/pubmed/id/16866307

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-7-26
pubmed:abstractText
The occurrence of puberty in the female is due to the interplay of central and peripheral mechanisms in which the hypothalamic-pituitary-ovarian axis regulates growth and gonadal function, as well as adipocyte hormone secretion. Hypothalamic GnRH mRNA expression increased at 3.5 months of age and declined by 6 months of age. Concomitant with the age related reduction in the oestrogen negative feedback on LH secretion was a decline in hypothalamic oestrogen receptor-alpha (ERalpha) expression and increased expression of repressor of ER activity gene (REA) at 210 days of age. Hypothalamic proopiomelanocortin expression increased at 6 months of age followed by increased expression of progesterone receptor (PR) membrane compliment-1 and steroid membrane binding protein gene at 210 days of age. This represents development of the endogenous opioid peptide-progesterone dependent LH inhibitory pathway. Adipose tissue leptin and insulin like growth factor-I (IGF-I) gene expression increased with age and adiposity. Pituitary transcription factors, steroidogenic factor 1 (SF1) and Lhx3, and LHbeta and FSHbeta gene expression increased with age. These results identify key hypothalamic and pituitary genes associated with changes in LH secretion and growth during pubertal development and adipose tissue genes and secreted proteins related to maturation of the neuroendocrine axis and puberty.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-44
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Gene expression in the brain-pituitary adipose tissue axis and luteinising hormone secretion during pubertal development in the gilt.
pubmed:affiliation
Animal Physiology Research Unit, USDA/ARS, Richard B. Russell Agriculture Research Center, PO Box 5677, Athens, GA 30604, USA. rbarb@saa.ars.usda.gov
pubmed:publicationType
Journal Article, Review