Linked Life Data

1686531

Source:http://linkedlifedata.com/resource/pubmed/id/1686531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-4-1
pubmed:abstractText
Formoterol is an innovative, highly potent, beta-2 selective adrenoceptor agonist combining the clinical advantages of rapid onset of action with a duration of action in excess of 12 h. In vitro, formoterol is a potent airway smooth muscle relaxant with high intrinsic activity. Formoterol appears to be retained in airway smooth muscle for extended periods since its relaxant effect on human airway smooth muscle is resistant to repeated washing and formoterol displays "reassertion" of relaxation after washout of a beta-adrenoceptor antagonist. In addition to airway smooth muscle relaxation, formoterol inhibits a range of acute inflammatory processes in animal models including eosinophil activation and infiltration of the airways, microvascular leakage, and antigen-induced mediator release from human lung. Whether these non-airway smooth muscle effects may influence chronic airway inflammation in clinical asthma remains to be determined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-0363
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-115
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pharmacology of formoterol: an innovative bronchodilator.
pubmed:affiliation
Pharmaceuticals Division, CIBA-GEIGY AG, Basel, Switzerland.
pubmed:publicationType
Journal Article, Review