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pubmed:abstractText |
The technique consisting of labelling antibodies with radionuclides is a promising approach for the diagnosis and therapy of human cancers. In this paper the chemical aspects of radiolabelling with macrocyclic metal complexes are dealt with. The choice of the radioisotope, its coordination chemistry, the design of the bifunctional macrocyclic ligand, and its attachment to the monoclonal antibody are discussed. Finally several newer ideas for a better application are presented.
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