|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
31
|
|
pubmed:dateCreated |
2006-8-2
|
|
pubmed:abstractText |
Evolutionists widely acknowledge that regulatory genetic changes are of paramount importance for morphological and genomic evolution. Nevertheless, mechanistic complexity and a paucity of data from nonmodel organisms have prevented testing and quantifying universal hypotheses about the macroevolution of gene regulatory mechanisms. Here, we use a phylogenetic approach to provide a quantitative demonstration of a previously hypothesized trend, whereby the evolutionary rate of repression or loss of gene expression regions is significantly higher than the rate of activation or gain. Such a trend is expected based on case studies in regulatory evolution and under models of molecular evolution where duplicated genes lose duplicated expression patterns in a complementary fashion. The trend is important because repression of gene expression is a hypothesized mechanism for the origin of evolutionarily novel morphologies through specialization.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-10101175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-10669421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-10823904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-10899140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-1090005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-11335113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-11585665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-11779815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-11859369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-11859370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-11861885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-12116640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-12734009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-12777501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-15356281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-16098631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-16237443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-448746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-7630416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-7723843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-7906390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864793-9585507
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
103
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
11637-41
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:16864793-Animals,
pubmed-meshheading:16864793-Drosophila melanogaster,
pubmed-meshheading:16864793-Evolution, Molecular,
pubmed-meshheading:16864793-Gene Duplication,
pubmed-meshheading:16864793-Gene Expression,
pubmed-meshheading:16864793-Genome,
pubmed-meshheading:16864793-Likelihood Functions,
pubmed-meshheading:16864793-Markov Chains,
pubmed-meshheading:16864793-Models, Genetic,
pubmed-meshheading:16864793-Phylogeny
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Repression and loss of gene expression outpaces activation and gain in recently duplicated fly genes.
|
|
pubmed:affiliation |
Ecology Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA. oakley@lifesci.ucsb.edu
|
|
pubmed:publicationType |
Journal Article
|
