Linked Life Data

1686461

Source:http://linkedlifedata.com/resource/pubmed/id/1686461

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-3-31
pubmed:abstractText
Several risk factors for cardiovascular disease are discussed, including blood pressure, left ventricular hypertrophy, stress and smoking. Beta-blockers have a modest effect in reversing increased left ventricular mass, compared with angiotensin converting enzyme (ACE) inhibitors, although beta-blockers are as effective as ACE inhibitors in reducing posterior wall and interventricular septal thickness. Coronary events and many risk factors show a circadian rhythm. Beta-blockers can reduce the mid-morning (0700-1000 h) risk of ischaemic events and myocardial infarction. Catecholamine levels peak at 0700-1000 h, and catecholamine-induced myocardial necrosis can be significantly reduced by beta-blockade. Beta-blockers appear to be more effective than calcium antagonists in modifying the mid-morning vulnerable period and reducing the duration of ischaemia. However, the problems of using surrogate endpoints are discussed. In young to middle-aged hypertensives, beta-blockers are more effective in primary prevention of myocardial events than diuretics, though this is not the case for the elderly. Beta-blockers are also more effective than calcium antagonists in reducing morbidity and mortality after a myocardial infarction (i.e. secondary prevention). Patients with hypertension associated with ischaemic heart disease are most likely to get maximal benefit from treatment with beta-blockers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S39-43
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Identification of patients at risk from ischaemic complications.
pubmed:affiliation
Cardiac Department, Wythenshawe Hospital, Manchester, UK.
pubmed:publicationType
Journal Article, Review