Linked Life Data

16864402

Source:http://linkedlifedata.com/resource/pubmed/id/16864402

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2006-7-25
pubmed:abstractText
Particulate air pollution is known to increase cardiovascular morbidity and mortality. Proposed mechanisms underlying this increase include effects on inflammation, coagulation factors, and oxidative stress, which could increase the risk of coronary events and atherosclerosis. The aim of this study was to examine whether short-term exposure to wood smoke affects markers of inflammation, blood hemostasis, and lipid peroxidation in healthy humans. Thirteen subjects were exposed to wood smoke and clean air in a chamber during two 4-h sessions, 1 wk apart. The mass concentrations of fine particles at wood smoke exposure were 240-280 mug/m3, and number concentrations were 95,000-180,000/cm3. About half of the particles were ultrafine (< 100 nm). Blood and urine samples were taken before and after the experiment. Exposure to wood smoke increased the levels of serum amyloid A, a cardiovascular risk factor, as well as factor VIII in plasma and the factor VIII/von Willebrand factor ratio, indicating a slight effect on the balance of coagulation factors. Moreover, there was an increased urinary excretion of free 8-iso-prostaglandin2alpha, a major F2-isoprostane, though this was based on nine subjects only, indicating a temporary increase in free radical-mediated lipid peroxidation. Thus, wood-smoke particles at levels that can be found in smoky indoor environments seem to affect inflammation, coagulation, and possibly lipid peroxidation. These factors may be involved in the mechanisms whereby particulate air pollution affects cardiovascular morbidity and mortality. The exposure setup could be used to establish which particle characteristics are critical for the effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1091-7691
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
845-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16864402-Acute-Phase Reaction, pubmed-meshheading:16864402-Adult, pubmed-meshheading:16864402-Air Pollutants, pubmed-meshheading:16864402-Biological Markers, pubmed-meshheading:16864402-Blood Coagulation, pubmed-meshheading:16864402-Dinoprost, pubmed-meshheading:16864402-Factor VIII, pubmed-meshheading:16864402-Female, pubmed-meshheading:16864402-Hematologic Tests, pubmed-meshheading:16864402-Humans, pubmed-meshheading:16864402-Inhalation Exposure, pubmed-meshheading:16864402-Lipid Peroxidation, pubmed-meshheading:16864402-Male, pubmed-meshheading:16864402-Middle Aged, pubmed-meshheading:16864402-Oxidative Stress, pubmed-meshheading:16864402-Particle Size, pubmed-meshheading:16864402-Questionnaires, pubmed-meshheading:16864402-Serum Amyloid A Protein, pubmed-meshheading:16864402-Smoke, pubmed-meshheading:16864402-Smoke Inhalation Injury, pubmed-meshheading:16864402-Wood, pubmed-meshheading:16864402-von Willebrand Factor
pubmed:year
2006
pubmed:articleTitle
Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation.
pubmed:affiliation
Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, Goteborg University, Goteborg, Sweden. lars.barregard@amm.gu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't