|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0030685,
umls-concept:C0038250,
umls-concept:C0205369,
umls-concept:C0229664,
umls-concept:C0231491,
umls-concept:C0391871,
umls-concept:C0662900,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1332823,
umls-concept:C1515021,
umls-concept:C1521970,
umls-concept:C1963578
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|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2006-7-25
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|
pubmed:abstractText |
AMD3100 is a new CXCR4 antagonist that induces a rapid release of hematopoietic progenitors from the bone marrow to the peripheral blood. We conducted a clinical study where patients with multiple myeloma and non-Hodgkin's lymphoma were treated with AMD3100 (A) to increase the number of peripheral blood progenitor cells (PBPCs) when given a mobilization regimen of granulocyte colony-stimulating factor (G-CSF, G). Because experimental data suggest that A+G-mobilized PBPCs are functionally different from G-mobilized PBPCs, we were interested in an intraindividual comparison of the gene expression profile of CD34+ cells in the two different settings.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0301-472X
|
|
pubmed:author |
pubmed-author:BridgerGaryG,
pubmed-author:CalandraGaryG,
pubmed-author:EcksteinVolkerV,
pubmed-author:FruehaufStefanS,
pubmed-author:GoldschmidtHartmutH,
pubmed-author:HoAnthony DAD,
pubmed-author:LaufsStephanieS,
pubmed-author:MaierPatrickP,
pubmed-author:SeegerTimonT,
pubmed-author:WagnerWolfgangW,
pubmed-author:WeinhardtStephanS,
pubmed-author:WenzFrederickF,
pubmed-author:XXX,
pubmed-author:ZellerW JensWJ
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
34
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1052-9
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
The CXCR4 antagonist AMD3100 releases a subset of G-CSF-primed peripheral blood progenitor cells with specific gene expression characteristics.
|
|
pubmed:affiliation |
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Stefan.Fruehauf@med.uni-heidelberg.de
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|
pubmed:publicationType |
Journal Article
|
