Linked Life Data

1686255

Source:http://linkedlifedata.com/resource/pubmed/id/1686255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-3-23
pubmed:abstractText
UD-CG-212 CL is a metabolite of pimobendan (UD-CG-115 BS), a non-glycosidic, non-adrenergic positive inotropic agent. In the present study we investigated the effect of UD-CG-212 CL on cat papillary muscles in the presence or absence of an intact endocardial endothelium. The endocardium was damaged by a very short detergent treatment. We demonstrated that, in muscles with an intact endocardial endothelium, UD-CG-212 CL induced a moderate, but significant inotropic effect resembling the changes induced by adrenoceptor agonists. Addition of an alpha- and or beta-blocker reduced this positive inotropic effect. The effect induced by UD-CG-212 CL, was completely abolished after the endocardial endothelium was damaged. We conclude that the endocardium played a modulatory role in the action of UD-CG-212 CL through the release of various factors with inotropic activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Role of the endocardium in the inotropic action of UD-CG-212 CL.
pubmed:affiliation
Department of Physiology, University of Antwerp, Belgium.
pubmed:publicationType
Journal Article, In Vitro