|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011209,
umls-concept:C0013227,
umls-concept:C0015087,
umls-concept:C0027950,
umls-concept:C0205349,
umls-concept:C0598629,
umls-concept:C1140680,
umls-concept:C1450054,
umls-concept:C1520166,
umls-concept:C1687871,
umls-concept:C1705187,
umls-concept:C2348767
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2007-1-16
|
|
pubmed:abstractText |
The objective of this study was to evaluate the anti-tumor efficacy and lack of systemic toxicity of paclitaxel when administered in pH-sensitive poly(ethylene oxide) (PEO)-modified poly(beta-amino ester) (PbAE) nanoparticles in mice bearing human ovarian adenocarcinoma (SKOV-3) xenograft.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0344-5704
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
477-84
|
|
pubmed:dateRevised |
2008-8-14
|
|
pubmed:meshHeading |
pubmed-meshheading:16862429-Animals,
pubmed-meshheading:16862429-Cell Line, Tumor,
pubmed-meshheading:16862429-Chemistry, Pharmaceutical,
pubmed-meshheading:16862429-Drug Delivery Systems,
pubmed-meshheading:16862429-Female,
pubmed-meshheading:16862429-Humans,
pubmed-meshheading:16862429-Hydrogen-Ion Concentration,
pubmed-meshheading:16862429-Mice,
pubmed-meshheading:16862429-Nanoparticles,
pubmed-meshheading:16862429-Neoplasm Transplantation,
pubmed-meshheading:16862429-Ovarian Neoplasms,
pubmed-meshheading:16862429-Paclitaxel,
pubmed-meshheading:16862429-Polyesters,
pubmed-meshheading:16862429-Polyethylene Glycols,
pubmed-meshheading:16862429-Transplantation, Heterologous
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model.
|
|
pubmed:affiliation |
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
