Source:http://linkedlifedata.com/resource/pubmed/id/16862278
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2006-7-24
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| pubmed:abstractText |
Diabetes mellitus (DM) is a highly prevalent complex genetic disorder. There has been a worldwide effort in the identification of susceptibility genes for DM and its complications, and the 5-10-methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein-E (APOE) genes have been considered good candidate susceptibility genes to this condition. The objectives of the present study were to determine if the 677T MTHFR and epsilon2/epsilon3/epsilon4 APOE alleles are risk factors for DM and for severity of diabetic retinopathy (DR). A total of 248 individuals were studied: 107 healthy individuals and 141 diabetic patients (46 with type 1 diabetes and 95 with type 2 diabetes), who also had DR (81 with non-proliferative DR and 60 with proliferative DR). The polymorphisms were analyzed by PCR followed by digestion with restriction enzyme or the single-nucleotide primer extension method. No evidence of association between the 677TT genotype of MTHFR gene and DM [cases: TT = 10/95 (10.6%); controls: TT = 14/107 (13%)] or with severity of DR was observed [cases: TT = 5/60 (8.5%); controls: TT = 9/81 (11.1%); P > 0.05]. We also did not find evidence of an association between APOE alleles and proliferative DR (epsilon2, epsilon3 and epsilon4 in cases: 9, 76, and 15%, and in controls: 5, 88, and 12%, respectively) but the carriers of epsilon2 allele were more frequent among patients with type 2 DM and DR than in controls [cases: 15/95 (15.8%); controls: 7/107 (6.5%); P < 0.05]. Therefore, our results suggest that the epsilon2 allele/APOE might be a risk factor for diabetes in the Brazilian population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0100-879X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
883-8
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| pubmed:meshHeading |
pubmed-meshheading:16862278-Aged,
pubmed-meshheading:16862278-Alleles,
pubmed-meshheading:16862278-Apolipoproteins E,
pubmed-meshheading:16862278-Case-Control Studies,
pubmed-meshheading:16862278-Diabetes Mellitus, Type 1,
pubmed-meshheading:16862278-Diabetes Mellitus, Type 2,
pubmed-meshheading:16862278-Diabetic Retinopathy,
pubmed-meshheading:16862278-Female,
pubmed-meshheading:16862278-Gene Frequency,
pubmed-meshheading:16862278-Genetic Predisposition to Disease,
pubmed-meshheading:16862278-Genotype,
pubmed-meshheading:16862278-Humans,
pubmed-meshheading:16862278-Male,
pubmed-meshheading:16862278-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:16862278-Middle Aged,
pubmed-meshheading:16862278-Polymerase Chain Reaction,
pubmed-meshheading:16862278-Polymorphism, Genetic,
pubmed-meshheading:16862278-Risk Factors,
pubmed-meshheading:16862278-Severity of Illness Index
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| pubmed:year |
2006
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| pubmed:articleTitle |
Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patients.
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| pubmed:affiliation |
Centro de Estudos do Genoma Humano, Instituto de Biociências, USP, São Paulo, SP, Brasil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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