Linked Life Data

1686189

Source:http://linkedlifedata.com/resource/pubmed/id/1686189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1992-3-26
pubmed:abstractText
Agents which are toxic to macrophages such as silica and caragheenan suppress genetic resistance to bone marrow allografts. However, these agents may also be toxic to other tissues and cannot be used for the establishment of long-term bone marrow chimerism. In this study, we used chemically insert carbon particles to blockade phagocytic cells, and succeeded in carrying out bone marrow allografts. Long-term survival of the recipient mice after bone marrow transplantation (BMT) was achieved without apparent evidence of graft-versus-host reaction (GVHR), although T-cells were not depleted in donor marrow cells. The hemopoietic system of the recipient mice was replaced by that of donor origin. These results indicate that phagocytic cells play an essential role, probably as effector cells in genetic resistance to bone marrow allograft.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0753-3322
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
417-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Prevention of genetic resistance to bone marrow allografts by reticuloendothelial system blockade.
pubmed:affiliation
Department of Biology, Faculty of Science, Niigata University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't