| pubmed-article:16861640 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C0010416 | lld:lifeskim |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16861640 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:16861640 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16861640 | pubmed:dateCreated | 2006-7-24 | lld:pubmed |
| pubmed-article:16861640 | pubmed:abstractText | Cell-mediated immunity plays an important role in immunity to the pathogenic fungus Cryptococcus neoformans. However, the antigen specificity of the T-cell response to C. neoformans remains largely unknown. In this study, we used two approaches to determine the antigen specificity of the T-cell response to C. neoformans. We report here that a diverse T-cell receptor (TCR) Vbeta repertoire was maintained throughout the primary response to pulmonary C. neoformans infection in immunocompetent mice. CD4+ T-cell deficiency resulted in relative expansion of all CD8+ T-cell subsets. During a secondary immune response, preferential usage of a TCR Vbeta subset in CD4+ T cells occurred in single individuals, but the preferences were "private" and not shared between individuals. Both CD4+ and CD8+ T cells from the secondary lymphoid tissues of immunized mice proliferated in response to a variety of C. neoformans antigens, including heat-killed whole C. neoformans, culture filtrate antigen, C. neoformans lysate, and purified cryptococcal mannoprotein. CD4+ and CD8+ T cells from the secondary lymphoid tissues of mice undergoing a primary response to C. neoformans proliferated in response to C. neoformans lysate. In response to stimulation with C. neoformans lysate, lung CD4+ and CD8+ T cells produced the effector cytokines tumor necrosis factor alpha and gamma interferon. These results demonstrate that a diverse T-cell response is generated in response to pulmonary C. neoformans infection. | lld:pubmed |
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| pubmed-article:16861640 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16861640 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16861640 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16861640 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16861640 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16861640 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:16861640 | pubmed:author | pubmed-author:ToewsGalen... | lld:pubmed |
| pubmed-article:16861640 | pubmed:author | pubmed-author:HuffnagleGary... | lld:pubmed |
| pubmed-article:16861640 | pubmed:author | pubmed-author:McDonaldRoder... | lld:pubmed |
| pubmed-article:16861640 | pubmed:author | pubmed-author:BallingerMega... | lld:pubmed |
| pubmed-article:16861640 | pubmed:author | pubmed-author:LindellDennis... | lld:pubmed |
| pubmed-article:16861640 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16861640 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:16861640 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16861640 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16861640 | pubmed:pagination | 4538-48 | lld:pubmed |
| pubmed-article:16861640 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16861640 | pubmed:meshHeading | pubmed-meshheading:16861640... | lld:pubmed |
| pubmed-article:16861640 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16861640 | pubmed:articleTitle | Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection. | lld:pubmed |
| pubmed-article:16861640 | pubmed:affiliation | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 6301 MSRB III, University of Michigan, Ann Arbor, Michigan 48109-0642, USA. | lld:pubmed |
| pubmed-article:16861640 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16861640 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16861640 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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